Evidence map›Paper›PMID 39537946›Full record

ArticleClinical rheumatology2025

TLR10 expression in unswitched memory B associates with the disease activity of patients with systemic lupus erythematosus.

Lumin Zhang, Linchang Yu, Quanfu Li, Meiping Ni, Qiongzhu Dong, Yufang Bao, Jinguan Zhang, Danping Ruan, Zhefeng Meng, Nannan Lai

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Updates on Toll-Like Receptor 10 Research.European journal of immunology · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lumin Zhang *Key Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Linchang Yu *Department of Intensive Care Unit, Shenzhen University General Hospital, Shenzhen, 518071, China.
Quanfu Li *Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, The Ministry of Education, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Meiping NiDepartment of Scientific Research, Minghang Hospital, Fudan University, Shanghai, 201199, China.
Qiongzhu DongKey Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Yufang BaoKey Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Jinguan ZhangKey Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Danping RuanDepartment of Stomatology, Minhang Hospital, Fudan University, Shanghai, 201199, China. danping_ruan@fudan.edu.cn.
Zhefeng MengDepartment of Scientific Research, Minghang Hospital, Fudan University, Shanghai, 201199, China. zhefengm@fuduan.edu.cn.
Nannan LaiKey Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer, Minhang Hospital, Fudan University, Shanghai, 201199, China. lainn@fudan.edu.cn.ORCID http://orcid.org/0000-0003-4562-8267

Funding

Key Laboratory of diagnosis and treatment of severe hepato-pancreatic diseases of Zhejiang Province G2023008National Natural Science Foundation of China 82303331PeiYou projects of Minhang Hospital 2023MHPY02Shanghai Municipal Health Commission 20234Y0096Xinmiao projects of Minhang Hospital 2024MHXM02
6 · The paper itself

Abstract

objectiveSystemic lupus erythematosus (SLE) is characterized by impaired B-cell function and a distinct B-cell phenotype. Toll-like receptor (TLR) 10 is highly expressed in human B cells and can regulate B-cell activation. Here, we examined the variations in TLR10 expression across B-cell subpopulations and its impact on the disease activity in SLE patients.

methodsThirty-one patients with stable SLE, 30 patients with active SLE, and 28 healthy controls (HCs) were recruited. Flow cytometry was performed to assess the prevalence of B-cell subpopulations and their TLR10 expression. The diagnostic value of unswitched memory B cells (UMB) and double-negative B cells (DNB) in relation to disease activity was determined. The correlations between TLR10 expressions in B-cell subpopulations and disease activity were further evaluated, respectively.

resultsCompared with the HCs, the stable patients exhibited significantly reduced Naive B proportion and elevated switched memory B and DNB proportion, while active patients presented markedly decreased UMB and increased DNB proportion. Furthermore, the receiver operating characteristics analysis revealed that UMB was more reliable than DNB in diagnosing SLE disease activity. Among the B-cell subsets, only the TLR10 expression in UMB was notably diminished in SLE patients, particularly in active patients. Importantly, TLR10 expression in UMB was negatively correlated with the disease activity.

conclusionUMB could serve as a promising biomarker for SLE disease activity, and the TLR10 expression in UMB was negatively correlated with the activity of SLE patients, suggesting that TLR10 might be involved in the disease progression of SLE by regulating the UMB function. Key Points • Active SLE patients exhibited reduced unswitched memory B cells and increased double-negative B cell proportions in blood. • Unswitched memory B cells are better predictors of disease activity in SLE than double-negative B cells. • TLR10 expression in unswitched memory B cells is markedly diminished in SLE patients. • TLR10 expression in unswitched memory B cells is negatively associated with SLE disease activity.

Indexed as

B-LymphocytesB-Lymphocyte SubsetsLupus Erythematosus, SystemicMemory B CellsToll-Like Receptor 10AdultCase-Control StudiesFemaleFlow CytometryHumansImmunologic MemoryMaleMiddle AgedSeverity of Illness IndexTLR10 protein, humanToll-Like Receptor 10B cellsDisease activitySystemic lupus erythematosusToll-like receptor 10Unswitched memory B

Identifiers

PMID39537946

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.