ArticleNature2024
NK2R control of energy expenditure and feeding to treat metabolic diseases.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
–field-weighted citation impact
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Who cites it
24 citing papers in PubMed.
- Article
- The emerging role of branched-chain amino acid metabolism in obesity.International journal of obesity (2005) · 2026Review
- Intracellular pocket and ICL2 motifs govern G-protein coupling bias in NKThe Journal of biological chemistry · 2026Article
- The evolving landscape of obesity pharmacotherapy.Nature reviews. Drug discovery · 2026Review
- A Lineup for Next Anti-Obesity Medicines: Beyond Incretin-Based Pharmacotherapy.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Structurally defining neurokinin selectivity to improve NK2R agonists.Nature structural & molecular biology · 2026Article
- Structural insights into neurokinin 2 receptor selectivity hold implications for obesity therapeutics.Nature structural & molecular biology · 2026Article
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Bioactive Phytoconstituents Targeting Energy Expenditure and Appetite to Combat Obesity: A Comprehensive Review.Current nutrition reports · 2026Review
- Hepatic GPR110 contributes to sex disparity in the development of MASH through oestrogen receptor α-dependent signalling.Nature metabolism · 2026Article
- Human Substance P Interactions with G Protein-Coupled Receptor NK1R Observed by NMR in Solution.Journal of the American Chemical Society · 2025Article
- Article
- Integrating population-level and cell-based signatures for drug repositioning.Bioinformatics (Oxford, England) · 2025Article
- A consensus guide to preclinical indirect calorimetry experiments.Nature metabolism · 2025Review
- Impact of Obesity on Immunity to the Influenza Virus: Gut Microbiota, Mechanisms, and Novel Therapeutic Strategies.Diseases (Basel, Switzerland) · 2025Review
- Shaping the future of cardiometabolic innovation: advances and opportunities.Nature metabolism · 2025Article
- Advancements and challenges in the management of obesity using pharmacotherapy (Review).Experimental and therapeutic medicine · 2025Review
- Review
- Assessing the effects of menopause and obesity on matriptase-2 and neurokinin B concentrations: A cross-sectional study.Journal of medical biochemistry · 2025Article
Corrections and comments
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Authors and funding
47 authors.
Frederike Sass *Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6144-7661
Tao Ma *Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2570-9449
Jeppe H EkbergNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Melissa KirigitiDivision of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
Mario G UreñaNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Lucile DolletNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Jenny M BrownNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5072-4491
Astrid L BasseNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6532-9232
Warren T YacawychDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Hayley B BurmNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Mette K AndersenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8227-1469
Thomas S NielsenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-9457-8000
Abigail J TomlinsonDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Oksana DmytiyevaNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Dan P ChristensenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Lindsay BaderDivision of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
Camilla T VoNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Yaxu WangCenter for Adipocyte Signaling (ADIPOSIGN), University of Southern Denmark, Odense, Denmark.
Dylan M RauschNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-6095-4891
Cecilie K KristensenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
María Gestal-MatoNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5096-2609
Wietse In Het PanhuisDepartment of Medicine, Division of Endocrinology and Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-4394-6387
Kim A SjøbergNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Stace KernodleDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Jacob E PetersenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2116-1626
Artem PavlovskyiNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Manbir SandhuCenter for Adipocyte Signaling (ADIPOSIGN), University of Southern Denmark, Odense, Denmark.
Ida MoltkeSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Marit E JørgensenClinical Research, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark.ORCID 0000-0001-8356-5565
Anders AlbrechtsenSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7306-031X
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5526-1070
M Madan BabuCenter for Adipocyte Signaling (ADIPOSIGN), University of Southern Denmark, Odense, Denmark.ORCID 0000-0003-0556-6196
Patrick C N RensenDepartment of Medicine, Division of Endocrinology and Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-8455-4988
Sander KooijmanDepartment of Medicine, Division of Endocrinology and Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-0014-5571
Randy J SeeleyDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3721-5625
Anna WorthmannDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Joerg HeerenDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-5647-1034
Tune H PersNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0207-4831
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8748-3831
Magnus B F GustafssonEmbark Laboratories, Copenhagen, Denmark.
Mads Tang-ChristensenEmbark Laboratories, Copenhagen, Denmark.
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8349-3028
Martin G MyersDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Paul KievitDivision of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
Thue W SchwartzNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0261-6904
Jakob B HansenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. jbh@embarklaboratories.com.
Zachary Gerhart-HinesNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. zpg@sund.ku.dk.ORCID 0000-0003-2981-4991
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3MIntestinal Reg3g as a mediator of dietary, pharmacological and surgical therapies for obesity and diabetesR01DK133140 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEELEY, RANDY J · 2022 to 2025
$2.1MNIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK133140
Abstract
The combination of decreasing food intake and increasing energy expenditure represents a powerful strategy for counteracting cardiometabolic diseases such as obesity and type 2 diabetes
Indexed as
Energy MetabolismFeeding BehaviorMetabolic DiseasesReceptors, Neurokinin-2AnimalsAppetiteBlood GlucoseCholesterolDiabetes Mellitus, Type 2Disease Models, AnimalFemaleHomeostasisHumansHyperinsulinismInsulin ResistanceLeptinBlood GlucoseCholesterolLeptinReceptors, Neurokinin-2Triglycerides
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.