Evidence map›Paper›PMID 39537928›Full record

ArticleNature2025

Prefrontal transthalamic uncertainty processing drives flexible switching.

Norman H Lam, Arghya Mukherjee, Ralf D Wimmer, Matthew R Nassar, Zhe Sage Chen, Michael M Halassa

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Decomposing the modulation of interactions between neuronal populations.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. A neural mechanism for online discovery of latent contexts.bioRxiv : the preprint server for biology · 2026
    Article
  11. Article
  12. Visual Motion Processing in The Tree Shrew Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  13. The geometry of context-dependent biased decisions during learning.bioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Frontoparietal Hubs Leverage Probabilistic Representations and Integrated Uncertainty to Guide Cognitive Flexibility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Norman H Lam *Department of Neuroscience, Tufts University, Boston, MA, USA.
Arghya Mukherjee *Department of Neuroscience, Tufts University, Boston, MA, USA.ORCID 0000-0002-3341-4408
Ralf D WimmerDepartment of Neuroscience, Tufts University, Boston, MA, USA.
Matthew R NassarDepartment of Neuroscience, Brown University, Providence, RI, USA.ORCID 0000-0002-5397-535X
Zhe Sage ChenDepartment of Neuroscience and Physiology, Grossman School of Medicine, New York University, New York, NY, USA.ORCID 0000-0002-6483-6056
Michael M HalassaDepartment of Neuroscience, Tufts University, Boston, MA, USA. Michael.Halassa@tufts.edu.ORCID 0000-0003-1386-0336

Funding

Thalamocortical cognitive networks in the healthy human brainP50MH132642 · NIMH · PRINCETON UNIVERSITY · PI Zhe Sage Chen · 2023 to 2026
$15.7M
Thalamic regulation of prefrontal dynamics in decision making under uncertaintyK99MH129613 · NIMH · TUFTS UNIVERSITY BOSTON · PI MUKHERJEE, ARGHYA · 2022 to 2023
$218k
NIMH NIH HHS K99 MH129613NIMH NIH HHS P50 MH132642
6 · The paper itself

Abstract

Making adaptive decisions in complex environments requires appropriately identifying sources of error

Indexed as

Cognitive FlexibilityCuesDecision MakingPrefrontal CortexThalamusAnimalsExecutive FunctionGyrus CinguliMaleMiceMice, Inbred C57BLNeural PathwaysNeuronsTupaiaUncertainty

Identifiers

PMID39537928
PMCPMC11841214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.