Evidence map›Paper›PMID 39537923›Full record

ArticleNature2024

Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1.

Victoria Godínez López, Marco Igor Valencia-Sánchez, Stephen Abini-Agbomson, Jonathan F Thomas, Rachel Lee, Pablo De Ioannes, Brian A Sosa, Jean-Paul Armache, Karim-Jean Armache

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victoria Godínez LópezDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Marco Igor Valencia-SánchezDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-7199-4546
Stephen Abini-AgbomsonDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-0148-6498
Jonathan F ThomasDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Rachel LeeDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-2501-5973
Pablo De IoannesDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-1944-3912
Brian A SosaDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Jean-Paul ArmacheDepartment of Biochemistry and Molecular Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.ORCID 0000-0001-9195-2282
Karim-Jean ArmacheDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA. karim-jean.armache@nyulangone.org.ORCID 0000-0002-0890-9513

Funding

Structural and functional analysis of gene silencingR01GM115882 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARMACHE, KARIM JEAN · 2015 to 2023
$3.4M
Molecular basis for aberrant de novo DNA methylation in cancerR01CA266978 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Karim Jean Armache, Chao Lu · 2022 to 2026
$2.6M
NCI NIH HHS R01 CA266978NIGMS NIH HHS R01 GM115882
6 · The paper itself

Abstract

Epigenetic inheritance of silent chromatin domains is fundamental to cellular memory during embryogenesis, but it must overcome the dilution of repressive histone modifications during DNA replication

Indexed as

Epigenesis, GeneticHistonesModels, MolecularNucleosomesPolycomb Repressive Complex 1UbiquitinationAnimalsChromatinCryoelectron MicroscopyHumansLysineProtein BindingProtein Structure, TertiaryRepressor ProteinsUbiquitin-Protein LigasesXenopusBMI1 protein, humanChromatinHistonesLysineNucleosomesPolycomb Repressive Complex 1Repressor ProteinsRNF2 protein, humanRYBP protein, humanUbiquitin-Protein Ligases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.