ArticleNature2025
Intravenous and intracranial GD2-CAR T cells for H3K27M
Erratum issuedAbstract readClinical Trial, Phase I
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 153 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 6 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
153 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Efficacy of CAR-T-Cell-Based Immunotherapies in Patients With Glioma: A Systematic Review and Meta-Analysis.Journal of cellular and molecular medicine · 2026Pooled it
- Locoregional and systemic adoptive cellular therapies for pediatric brain tumors: a systematic review of CAR‑T, TCR‑engineered T cells, and NK cell strategies.Neurosurgical review · 2026Pooled it
- Chimeric Antigen Receptor-T Cell Therapy for Pediatric and Young Adult Primary Central Nervous System Tumors: A Systematic Review of Early Phase Clinical Trials with a Focus on Diffuse Midline Glioma.Targeted oncology · 2026Pooled it
- Systemic versus intracranial immunotherapy delivery in pediatric malignant brain tumors: a systematic review, meta-analysis, and meta-regression.European journal of pediatrics · 2026Pooled it
- Locoregional delivery of CAR T cells in high-grade gliomas: a systematic analysis of safety, efficacy, and emerging biomarkers of response.Journal for immunotherapy of cancer · 2026Pooled it
- Efficacy and safety of immunotherapy in pediatric malignant brain tumors: a systematic review and exploratory meta-analysis.Frontiers in oncology · 2026Pooled it
- Tumor-targeted interferon-α gene therapy for glioblastoma: a phase 1 trial.Nature medicine · 2026Trial
- Adult Thalamic Diffuse Midline Glioma, H3 K27-Altered, WithJournal of medical cases · 2026Article
- Paediatric thalamic tumours: a predictive MR phenotype.Neuroradiology · 2026Article
- Abundant CD8British journal of cancer · 2026Article
- The DIPG/DMG National Tumor Board: The power of advocacy.Neuro-oncology pediatrics · 2026Article
- mRNA CAR T cells promote tolerable, tunable therapy in preclinical high grade glioma models.Molecular therapy. Oncology · 2026Article
- Oncolytic viruses enhance CAR-T activity for the treatment of pediatric diffuse midline gliomas.Molecular therapy. Oncology · 2026Article
- PLP1-triggered NOT gate to address neurotoxicity risk of PSMA-targeted prostate cancer therapy.Journal for immunotherapy of cancer · 2026Article
- Bioengineered cell therapies for pediatric solid tumors: unmet needs and a measurement-integrated approach.Progress in biomedical engineering (Bristol, England) · 2026Review
- Clinical Outcomes and New Treatments in Pediatric Brain Tumors.Current oncology (Toronto, Ont.) · 2026Article
- Exon-skipping antisense oligonucleotides for H3.3K27M-altered diffuse midline glioma therapy.Molecular therapy. Nucleic acids · 2026Article
- Chimeric antigen receptor (CAR)-T cell therapy for solid tumors in pediatric patients: current breakthroughs, dilemmas, and strategies.Experimental hematology & oncology · 2026Review
- Intracranial delivery of B7-H3-targeting CAR-T cells for recurrent glioblastoma: a phase 1 trial.Nature medicine · 2026Article
- The evolving role of cytokines for CAR-T cell manufacturing and beyond.Nature biomedical engineering · 2026Review
93 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
54 authors.
Michelle MonjeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. mmonje@stanford.edu.ORCID 0000-0002-3547-237X
Jasia MahdiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Robbie MajznerDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6969-8011
Kristen W YeomDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0001-9860-3368
Liora M SchultzDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Rebecca M RichardsDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Valentin BarsanDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Kun-Wei SongDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4472-230X
Jen KamensDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Christina BaggottStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Michael KunickiStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6630-6289
Skyler P RietbergStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Alexandria Sung LimStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Agnes ReschkeDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Sharon MavroukakisStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Emily EgelerStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5173-0335
Jennifer MoonStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Shabnum PatelStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Harshini ChinnasamyStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Courtney EricksonStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Ashley JacobsStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Allison K DuhDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Ramya TunuguntlaStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Dorota Danuta KlyszStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6733-6110
Carley FowlerStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Sean GreenDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Barbara BeebeStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Casey CarrStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Michelle FujimotoStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Annie Kathleen BrownStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Ann-Louise G PetersenStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Catherine McIntyreCellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.
Aman SiddiquiCellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.
Nadia Lepori-BuiCellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.
Katlin VillarCellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.
Kymhuynh PhamCellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.
Rachel BoveCellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.
Eric MusaCellular Therapy Facility, Stanford Health Care, Palo Alto, CA, USA.
Warren D ReynoldsStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Adam KuoStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Snehit PrabhuStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Lindsey RasmussenDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, Stanford University, Stanford, CA, US.
Timothy T CornellDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, Stanford University, Stanford, CA, US.
Sonia PartapDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Paul G FisherDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1196-1590
Cynthia J CampenDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3519-1375
Gerald GrantDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Laura ProloDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Xiaobu YeDepartment of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Bita SahafStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Kara L DavisDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-7182-2592
Steven A FeldmanStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Sneha RamakrishnaDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA. ramakrs@stanford.edu.ORCID 0000-0001-7445-3190
Crystal MackallDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA. cmackall@stanford.edu.ORCID 0000-0001-6323-4304
Funding
Developing Safe and Effective GD2-CAR T Cell Therapy for Diffuse Midline GliomasR01CA263500 · NCI · STANFORD UNIVERSITY · PI MACKALL, CRYSTAL, MONJE-DEISSEROTH, MICHELLE · 2021 to 2025
$3.3MNOT-gated CAR T cells to overcome on-target, off-tumor toxicity in AMLK08CA266930 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Rebecca Margaret Richards · 2022 to 2026
$1.2MDefining Pre-treatment Correlates of Patient GD2 CAR T Cell Exhaustion and Memory Using Multi-Dimensional Immune ProfilingK08CA267057 · NCI · STANFORD UNIVERSITY · PI Sneha Ramakrishna · 2022 to 2026
$1.1MNCI NIH HHS K08 CA266930NCI NIH HHS K08 CA267057NCI NIH HHS R01 CA263500
Abstract
H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref.
Indexed as
Brain NeoplasmsGangliosidesGliomaHistonesImmunotherapy, AdoptiveReceptors, Chimeric AntigenT-LymphocytesAdultBrain Stem NeoplasmsFemaleHumansMaleMaximum Tolerated DoseMiddle AgedMutationYoung Adultganglioside, GD2GangliosidesHistonesReceptors, Chimeric Antigen
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.