ArticleScientific reports2024
Elevated neutrophil percentage-to-albumin ratio predicts increased all-cause and cardiovascular mortality among individuals with diabetes.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Development and validation of a neutrophil percentage to albumin ratio-based nomogram for predicting survival in patients with locally advanced gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Neutrophil-Linked Inflammatory Mechanisms and Biomarkers in Diabetic Microvascular Complications.Diabetes & metabolism journal · 2026Review
- Association Between Neutrophil Percentage-to-Albumin Ratio (NPAR) and the Prognosis of Non-Small-Cell Lung Cancer.Cancers · 2026Article
- The neutrophil-percentage-to-albumin ratio (NPAR) shows a nonlinear correlation with all-cause mortality in patients with anemia.Clinical and experimental medicine · 2026Article
- Neutrophil-to-Albumin Ratio Mediates the Association Between Life's Crucial 9 and Sarcopenia: A Cross-Sectional Study.Health science reports · 2026Article
- Association between neutrophil percentage-to-albumin ratio and all-cause mortality in patients post-cardiac surgery: a retrospective cohort study.Molecular and cellular biochemistry · 2026Article
- Impact of sex on the association between neutrophil percentage-to-albumin ratio and mortality in perioperative patients with chronic kidney disease: a retrospective analysis of the INSPIRE database.Perioperative medicine (London, England) · 2026Article
- Prognostic Significance of Lactate Dehydrogenase-to-Albumin Ratio and Neutrophil Percentage-to-Albumin Ratio in IgA Nephropathy.Biomedicines · 2026Article
- Neutrophil-to-albumin ratio and all-cause mortality in critically ill patients with cerebral infarction: a retrospective cohort study using the MIMIC-IV database.European journal of medical research · 2026Article
- Association between neutrophil percentage-to-albumin ratio and bone mineral density and prevalent osteoporosis in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- A novel inflammatory-nutritional index: NPAR-correlates with the severity of type 2 diabetic foot ulcers.Frontiers in nutrition · 2026Article
- Neutrophil Percentage-to-Albumin Ratio as a Predictor of Urinary Tract Infection in Patients with Urinary Stone Disease: Development a Novel User-Friendly Tool.Journal of inflammation research · 2026Article
- Association Between Neutrophil Percentage-to-Albumin Ratio and All-Cause Mortality and Cardiovascular Events in Patients with Diabetic Foot Ulcers: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Neutrophil percentage to albumin ratio and advanced cardiovascular-kidney-metabolic syndrome in diabetes: a machine learning approach.European journal of medical research · 2025Article
- To explore the association between the neutrophil percentage to albumin ratio and low bone mineral density/osteoporosis based on NHANES 2011-2018.Scientific reports · 2025Article
- Preoperative neutrophil percentage-to-albumin ratio as a postoperative AKI predictor in non-cardiac surgery: a retrospective cohort secondary analysis.Scientific reports · 2025Article
- Neutrophil percentage to albumin ratio predicts all-cause and cardiovascular mortality in patients with diabetes or prediabetes from NHANES 1999-2018.Scientific reports · 2025Article
- Association between saturated and polyunsaturated fatty acid proportions in total fat intake and mortality risk: mediation by the neutrophil percentage-to-albumin ratio.Lipids in health and disease · 2025Article
- Neutrophil percentage-to-albumin ratio as predictor for mortality in patients undergoing endoscopic intervention for variceal hemorrhage.European journal of medical research · 2025Article
- Prognostic effect of neutrophil percentage-to-albumin ratio (NPAR) on all-cause and cardiovascular mortality in diabetic kidney disease (DKD): NHANES 1999-2018.Diabetology & metabolic syndrome · 2025Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence regarding the neutrophil percentage-to-albumin ratio (NPAR) and mortality risk in diabetes patients is scarce. This study aimed at investigating the prognostic value of NPAR for mortality in patients with diabetes. This retrospective analysis was conducted on 6,962 diabetic patients from the NHANES database. Restricted cubic spline (RCS) was used to visualize the association of the NPAR with mortality risk. Weighted multivariable Cox regression models and subgroup analyses were adopted to assess the association of the NPAR with all-cause and cardiovascular mortality. Time-dependent receiver operating characteristic curve (ROC) analysis was conducted to evaluate the accuracy of the NPAR in predicting survival outcomes. Mediation analysis explored the indirect impact of NPAR on mortality mediated through eGFR. During a median follow-up of 6.7 years, there were 1,804 deaths were recorded, including 602 cardiovascular deaths. The RCS regression showed that NPAR has a J-shaped association with all-cause mortality, and a positive linear association with CVD mortality. Each one-unit increase in NPAR was linked with a 14% and 12% increased risk of all-cause and cardiovascular mortality, respectively. The association was consistent in subgroup analyses based on age, sex, race, BMI, hypertension, CKD, and history of CVD. The time-dependent ROC curve showed the area under the curve of were 0.809 for all-cause mortality, and 0.780 for CVD mortality. In mediation analyses, eGFR partially mediated these relationships. An elevated NPAR is independently associated with increased all-cause and cardiovascular mortality in diabetes patients.
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