SynthesisNature communications2024
Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Age and Treatment Efficacy in Myasthenia Gravis: A Systematic Review, Meta-Analysis, and Meta-Regression.European journal of neurology · 2026Pooled it
- Myasthenia Gravis With Acetylcholine Receptor Antibodies in the Very Old: Treatment Challenges and Diagnostic Pitfalls.European journal of neurology · 2026Pooled it
- Genome-Wide and Locus-Level Analyses Reveal Modest, Heterogeneous Genetic Sharing Between Alzheimer's Disease and Myasthenia Gravis.International journal of molecular sciences · 2026Article
- Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma.Nature communications · 2026Article
- Article
- CFDFrontiers in immunology · 2026Article
- Identification of rs28362336 as a risk SNP for generalized myasthenia gravis and its impact on HCG27 regulation.PloS one · 2026Article
- Immunological Targets in Generalized Myasthenia Gravis Treatment: Where Are We Going Now?Brain sciences · 2025Review
- Causal Variants in CHRNA1 and CHRNB1 Genes for Anti-acetylcholine Receptor Antibody Positive Myasthenia Gravis: Evidence from Bayesian Fine-Mapping and Genetic Association Study.Molecular neurobiology · 2025Article
- Nicotine, Alcohol Consumption, and Risk of Myasthenia Gravis: Results From the Swedish Nationwide GEMG Study.Neurology · 2025Article
- Toll-like receptors and their role in the pathogenesis of myasthenia gravis: a comprehensive review.Frontiers in immunology · 2025Review
- Serum cystatin C as a potential biomarker for generalized acetylcholine receptor antibody-positive myasthenia gravis.Frontiers in immunology · 2025Article
- Myasthenia gravis complicated with autoimmune encephalitis: a review.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors.
Alice BraunDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.ORCID 0000-0003-1145-0261
Sudhanshu ShekharDepartment of Genetics, University of North Carolina at Chapel Hill, North Carolina, USA.ORCID 0000-0002-1827-5059
Daniel F LeveyDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, USA.ORCID 0000-0001-8431-9569
Peter StraubVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Julia KraftDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.ORCID 0000-0001-7306-1179
Georgia M PanagiotaropoulouDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.
Karl HeilbronDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.
Swapnil AwasthiDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.
Rafael Meleka HannaDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.
Sarah HoffmannDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.
Maike SteinDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.ORCID 0009-0002-1514-8385
Sophie LehnererDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.
Philipp MergenthalerDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.ORCID 0000-0002-9753-6711
Abdelrahman G ElnahasInstitute of Genomics, University of Tartu, Tartu, Estonia.
Apostolia TopaloudiDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Maria KorominaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-8843-082X
Teemu PalviainenInstitute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-7847-8384
Bergrun AsbjornsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID 0000-0003-4693-1209
Hreinn StefanssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Astros Th SkuladóttirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID 0000-0002-5048-0933
Ingileif JónsdóttirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID 0000-0001-8339-150X
Kari StefanssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID 0000-0003-1676-864X
Kadri ReisInstitute of Genomics, University of Tartu, Tartu, Estonia.
Tõnu EskoInstitute of Genomics, University of Tartu, Tartu, Estonia.
Aarno PalotieInstitute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-2527-5874
Frank LeypoldtDepartment of Neurology, Kiel University, Kiel, Schleswig-Holstein, Germany.ORCID 0000-0002-8972-515X
Murray B SteinDepartment of Psychiatry and School of Public Health, University of California San Diego, La Jolla, California, USA.ORCID 0000-0001-9564-2871
Pierre Fontanillas23andMe, Inc., Sunnyvale, California, USA.ORCID 0000-0002-8944-4454
Estonian Biobank Research Team
23andMe Research Team
Jaakko KaprioInstitute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455
Joel GelernterDepartment of Psychiatry, Yale School of Medicine, West Haven, CT, USA.ORCID 0000-0002-4067-1859
Lea K DavisVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-5143-2282
Peristera PaschouDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Martijn R TannemaatLeiden University Medical Center, Department of Neurology, Leiden, Zuid Holland, Netherlands.ORCID 0000-0003-2929-0390
Jan J G M VerschuurenLeiden University Medical Center, Department of Neurology, Leiden, Zuid Holland, Netherlands.ORCID 0000-0002-4572-1501
Gregor KuhlenbäumerDepartment of Neurology, Kiel University, Kiel, Schleswig-Holstein, Germany.
Peter K GregersenFeinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY, USA.ORCID 0000-0003-1613-1518
Maartje G HuijbersLeiden University Medical Center, Department of Neurology, Leiden, Zuid Holland, Netherlands.ORCID 0000-0002-6082-5042
Frauke StascheitDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.ORCID 0000-0001-5306-7880
Andreas MeiselDepartment of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany.ORCID 0000-0001-7233-5342
Stephan RipkeDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Berlin, Germany. sripke@broadinstitute.org.ORCID 0000-0003-3622-835X
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MPharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4MUnderstanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH, RODEN, DAN M · 2015 to 2019
$13.0MThe Genetic Epemiology of Multiple SclerosisR01NS032830 · NINDS · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 1995 to 2010
$8.9MEpidemiologic Architecture for Genes Linked to Environment (EAGLE)U01HG004798 · NHGRI · VANDERBILT UNIVERSITY · PI CRAWFORD, DANA C · 2008 to 2013
$8.8MVESPA: Vanderbilt Electronic Systems for Pharmacogenomic AssessmentRC2GM092618 · NIGMS · VANDERBILT UNIVERSITY · PI DENNY, JOSHUA C., RODEN, DAN M · 2009 to 2010
$6.4MVanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0MUnderstanding the genetic risk underlying racial disparities in uterine fibroids - Diversity SupplementR01HD074711 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VELEZ EDWARDS, DIGNA R · 2013 to 2017
$2.9MAutomated Storage and Retrieval of Biological SystemsS10RR025141 · NCRR · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2008 to 2008
$988kBLRD VA IK2 BX005058CSRD VA I01 CX001849NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS U19 HL065962NICHD NIH HHS R01 HD074711NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NINDS NIH HHS R01 NS032830
Abstract
Myasthenia gravis (MG) is a rare autoantibody-mediated disease affecting the neuromuscular junction. We performed a genome-wide association study of 5708 MG cases and 432,028 controls of European ancestry and a replication study in 3989 cases and 226,643 controls provided by 23andMe Inc. We identified 12 independent genome-wide significant hits (P < 5e
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyMultifactorial InheritanceMyasthenia GravisAdultAge of OnsetAllelesCase-Control StudiesFemaleGenetic LociHumansMaleMiddle AgedPolymorphism, Single NucleotideWhite People
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.