Evidence map›Paper›PMID 39537591›Full record

ArticleNature communications2024

Exactly defined molecular weight poly(ethylene glycol) allows for facile identification of PEGylation sites on proteins.

Maria J Burggraef, Adam Oxley, Naveed A Zaidi, Pedro R Cutillas, Piers R J Gaffney, Andrew G Livingston

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria J BurggraefSchool of Engineering and Materials Science, Queen Mary University of London, London, UK.
Adam OxleySchool of Engineering and Materials Science, Queen Mary University of London, London, UK.ORCID 0000-0003-2100-7183
Naveed A ZaidiSchool of Engineering and Materials Science, Queen Mary University of London, London, UK.
Pedro R CutillasBarts Cancer Institute, Queen Mary University of London, London, UK.ORCID 0000-0002-3426-2274
Piers R J GaffneySchool of Engineering and Materials Science, Queen Mary University of London, London, UK.
Andrew G LivingstonSchool of Engineering and Materials Science, Queen Mary University of London, London, UK. a.livingston@qmul.ac.uk.ORCID 0000-0002-7916-3026

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PEGylation (the covalent attachment of one or more poly(ethylene glycol) (PEG) units to a therapeutic) is a well-established technique in the pharmaceutical industry to increase blood-residence time and decrease immunogenicity. A challenging aspect of PEGylation is the dispersity of PEGylation agents, which results in batch-to-batch variations and analytical limitations. Herein, we present an approach to overcome these limitations by manufacturing a defined molecular weight (dispersity-free) PEGylation agent. We synthesise a defined molecular weight (M

Indexed as

Molecular WeightPolyethylene GlycolsSerum Albumin, BovineAnimalsCattlemonomethoxypolyethylene glycolPolyethylene GlycolsSerum Albumin, Bovine

Identifiers

PMID39537591
PMCPMC11560933

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.