Evidence map›Paper›PMID 39537335›Full record

ArticleJournal of internal medicine2025

Primary glomerular diseases and long-term adverse health outcomes: A nationwide cohort study.

Anne-Laure Faucon, Stefania Lando, Charikleia Chrysostomou, Julia Wijkström, Sigrid Lundberg, Rino Bellocco, Mårten Segelmark, Marie Evans, Juan-Jesús Carrero

Abstract read
In one paragraph

Article in Journal of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne-Laure FauconDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6716-1157
Stefania LandoDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Charikleia ChrysostomouDepartment of Nephrology, Karolinska University Hospital, Stockholm, Sweden.
Julia WijkströmDepartment of Nephrology, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-6183-5878
Sigrid LundbergDepartment of Medical Specialist Care, Nephrology Clinic, Danderyd University Hospital, Stockholm, Sweden.
Rino BelloccoDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mårten SegelmarkDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Marie EvansDepartment of Nephrology, Karolinska University Hospital, Stockholm, Sweden.
Juan-Jesús CarreroDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-4763-2024

Funding

Medication Use and Adverse Events in CKDR01DK115534 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Alexander R Chang, Morgan Erika Grams · 2018 to 2026
$5.7M
CSL ViforNIDDK NIH HHS R01 DK115534Region Stockholm (Center of Innovative MEDicine (CIMED), and ALF Medicine)Swedish Heart and Lung FoundationSwedish Research Council 2023-01807US National Institute of Health NIH R01DK115534
6 · The paper itself

Abstract

backgroundAlthough glomerular diseases are the third most frequent cause of end-stage kidney disease worldwide, little is known about their long-term outcomes.

methodsIn patients with chronic kidney disease (CKD) stage 3-5 enrolled in the Swedish Renal Registry, we compared risks of hospitalization, kidney replacement therapy (KRT), major cardiovascular events (MACE), and death of the four most frequent primary glomerular diseases (IgA nephropathy [IgAN], focal segmental glomerulosclerosis [FSGS], minimal change disease [MCD], and membranous nephropathy [MN]), and patients with CKD due to the most common non-communicable diseases (control-CKD).

resultsWe identified 2396 patients with glomerular disease (97% biopsy-proven, 69% men, 57 years, eGFR 29 mL/min/1.73 m

conclusionDespite having a lower relative risk of hospitalization, cardiovascular events and mortality, patients with IgAN and FSGS are at higher risk of CKD progression than the most common etiologies of CKD, emphasizing the need for more stringent treatment strategies in these patients.

Indexed as

Glomerulosclerosis, Focal SegmentalHospitalizationAdultAgedCardiovascular DiseasesCohort StudiesFemaleGlomerular Filtration RateGlomerulonephritis, IGAGlomerulonephritis, MembranousHumansMaleMiddle AgedNephrosis, LipoidRegistriesRenal Insufficiency, Chronicchronic kidney diseasefocal segmental glomerulosclerosisIgA nephropathyoutcomesprimary glomerular disease

Identifiers

PMID39537335
PMCPMC11636430

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.