Evidence map›Paper›PMID 39536968›Full record

ArticleThe Journal of nutrition2025

A Metabolome Wide Association Study of Fruit and Vegetable Consumption and Associations with Cardiovascular Disease Risk Factors: The International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP) Study.

Linda M Oude Griep, Elena Chekmeneva, Linda Van Horn, Queenie Chan, Martha L Daviglus, Gary Frost, Elaine Holmes, Timothy Md Ebbels, Paul Elliott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linda M Oude GriepMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. Electronic address: linda.oudegriep@mrc-epid.cam.ac.uk.
Elena ChekmenevaDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Linda Van HornDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States.
Queenie ChanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Martha L DaviglusInstitute for Minority Health Research, University of Illinois, Chicago, Illinois, United States.
Gary FrostDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Elaine HolmesDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom; Institute of Health Futures, Murdoch University, Perth, Western Australia, Australia.
Timothy Md EbbelsDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; MRC Centre for Environment and Health, Imperial College London, London, United Kingdom.

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
INTL POPULATION STUDY ON MACRONUTRIENTS AND BP INTERMAPR01HL050490 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 1995 to 2013
$7.3M
Metabolomics-Measured Urinary Metabolites, Diet & BP, 17 Population Samples: INTER01HL084228 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 2007 to 2014
$4.2M
Metabolic Pathways Underlying the Contrasting Sodium-BP and DASH/OmniHeart-BP RelationshipsR01HL135486 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVIGLUS, MARTHA L, ELLIOTT, PAUL · 2017 to 2020
$2.6M
AMINO ACIDS IN URINE, DIET &BP: INT'L POPULATION STUDYR01HL065461 · NHLBI · NORTHWESTERN UNIVERSITY · PI DAVIGLUS, MARTHA L · 2000 to 2003
$1.0M
NHLBI NIH HHS R01 HL050490NHLBI NIH HHS R01 HL065461NHLBI NIH HHS R01 HL084228NHLBI NIH HHS R01 HL135486NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

backgroundEpidemiologic evidence linking blood pressure (BP) and body weight-lowering effects with fruit and vegetable consumption mostly relies on self-reported dietary assessment prone to misreport and under- or overestimation of relationships.

objectivesWe aimed to characterize objective 24-h urinary metabolites and a derived metabolite score associated with fruit and vegetable intake and assessed their associations with BP and BMI, with validation across cohorts.

methodsWe used untargeted proton nuclear magnetic resonance spectroscopy (

resultsWe characterized 11

conclusionsWe identified

Indexed as

Cardiovascular DiseasesDietFruitMetabolomeVegetablesAdultAgedBlood PressureCross-Sectional StudiesFemaleHeart Disease Risk FactorsHumansMaleMiddle Aged24-h dietary recallsBiomarkersblood pressurebody mass indexcardiovascular disease risk factorsfruit and vegetablesurinary metabolites

Identifiers

PMID39536968
PMCPMC11795696

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.