Evidence map›Paper›PMID 39536925›Full record

ArticleRespiratory physiology & neurobiology

Enhanced phrenic motor neuron BDNF expression elicited by daily acute intermittent hypoxia is undermined in rats with chronic cervical spinal cord injury.

Aaron A Jones, Jose R Oberto, Marissa C Ciesla, Yasin B Seven, Latoya L Allen, Elisa J Gonzalez-Rothi, Gordon S Mitchell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. An update on spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aaron A JonesBreathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, FL 32610, USA.
Jose R ObertoBreathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, FL 32610, USA.
Marissa C CieslaBreathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, FL 32610, USA.
Yasin B SevenBreathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, FL 32610, USA.
Latoya L AllenBreathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, FL 32610, USA.
Elisa J Gonzalez-RothiBreathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, FL 32610, USA.
Gordon S MitchellBreathing Research and Therapeutics Center, Department of Physical Therapy and McKnight Brain Institute, University of Florida, FL 32610, USA. Electronic address: gsmitche@phhp.ufl.edu.

Funding

Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
Functional mapping of peripheral and central circuits for airway protection and breathingOT2OD023854 · OD · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C · 2016 to 2020
$10.8M
Training In Rehabilitation and Neuromuscular PlasticityT32HD043730 · NICHD · UNIVERSITY OF FLORIDA · PI DAVID D FULLER · 2003 to 2026
$5.3M
Optimizing respiratory plasticity with chronic cervical SCIR01HL147554 · NHLBI · UNIVERSITY OF FLORIDA · PI MITCHELL, GORDON S. · 2019 to 2022
$2.9M
Nanoparticle-Based Drug Delivery Targeting the Respiratory Neural NetworkR21NS119862 · NINDS · UNIVERSITY OF FLORIDA · PI SEVEN, YASIN B · 2021 to 2021
$424k
NHLBI NIH HHS R01 HL147554NICHD NIH HHS K12 HD055929NICHD NIH HHS T32 HD043730NIH HHS OT2 OD023854NINDS NIH HHS R21 NS119862
6 · The paper itself

Abstract

Acute intermittent hypoxia (AIH) elicits spinal neuroplasticity and is emerging as a potential therapeutic modality to improve respiratory and non-respiratory motor function in people with chronic incomplete spinal cord injury (SCI). Brain-derived neurotrophic factor (BDNF) is necessary and sufficient for moderate AIH-induced phrenic long-term facilitation, a well-studied form of respiratory motor plasticity. Repetitive daily AIH (dAIH) enhances BDNF expression within the phrenic motor neurons of normal rats, but its effects on BDNF after chronic cervical spinal cord injury (cSCI) are unknown. In contrast to AIH, chronic intermittent hypoxia (CIH), simulating that experienced during sleep apnea, elicits neuropathology and undermines plasticity. Here, we tested the hypothesis that daily AIH vs CIH differentially regulate phrenic motor neuron BDNF expression in spinally intact and injured rats. Rats with and without C2 hemisection (C2Hx; 8 weeks post-injury) were exposed to 28 days of: 1) sham normoxia (Nx, 21 % O

Indexed as

Brain-Derived Neurotrophic FactorCervical CordDisease Models, AnimalHypoxiaMotor NeuronsPhrenic NerveRats, Sprague-DawleySpinal Cord InjuriesAnimalsCervical VertebraeChronic DiseaseMaleNeuronal PlasticityRatsBdnf protein, ratBrain-Derived Neurotrophic FactorAcute intermittent hypoxiaBrain-derived neurotrophic factorCervical hemisectionPhrenic motor neuronRespiratory neuroplasticitySpinal cord injury

Identifiers

PMID39536925
PMCPMC13196730

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.