Evidence map›Paper›PMID 39536711›Full record

ArticleImmunity2024

Mx1-ing it up-Mitochondrial relay for interferon-dependent, unconventional IL-1β release in SLE monocytes.

Andrea Dorfleutner, Christian Stehlik, Caroline A Jefferies

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Andrea DorfleutnerDepartment of Academic Pathology and Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Christian StehlikDepartment of Academic Pathology, Department of Biomedical Sciences and Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Caroline A JefferiesKao Autoimmunity Institute and Department of Medicine, Division of Rheumatology and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: caroline.jefferies@cshs.org.

Funding

Regulation of cytosolic pattern recognition receptor signaling in macrophagesR01AI099009 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI STEHLIK, CHRISTIAN · 2013 to 2022
$4.7M
A novel mechanism for NLRP3 inflammasome activation in human macrophagesR01AI165797 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI DORFLEUTNER, ANDREA, STEHLIK, CHRISTIAN · 2022 to 2025
$3.8M
A novel essential inflammasome component propagating inflammatory responsesR01AI134030 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI DORFLEUTNER, ANDREA, STEHLIK, CHRISTIAN · 2019 to 2023
$3.1M
CARD-only protein regulation of cytosolic Pattern Recognition Receptor signalingR01AI140702 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DORFLEUTNER, ANDREA, STEHLIK, CHRISTIAN · 2018 to 2022
$2.9M
Sex and gender differences in lupus - intersection between immunometabolism, epigenetic remodeling and cardiac involvementR01AI164504 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI JEFFERIES, CAROLINE · 2021 to 2024
$2.3M
TRIM21 as a regulator of UVB- and cytosolic DNA-driven IFN responses in lupusR56AR078279 · NIAMS · CEDARS-SINAI MEDICAL CENTER · PI JEFFERIES, CAROLINE · 2022 to 2022
$367k
NIAID NIH HHS R01 AI099009NIAID NIH HHS R01 AI134030NIAID NIH HHS R01 AI140702NIAID NIH HHS R01 AI164504NIAID NIH HHS R01 AI165797NIAMS NIH HHS R56 AR078279
6 · The paper itself

Abstract

The role of type I interferon (IFN-I) in systemic lupus erythematosus (SLE) is well documented, but the role of interleukin (IL)-1β remains elusive. In this issue of Immunity, Caielli et al. identified an SLE monocyte population coproducing IL-1β and IFN-I and described how mitochondrial nucleic-acid-containing RBCs engage cGAS/STING, RIG-I, MDA5, and NLRP3 for unconventional IL-1β release.

Indexed as

Interleukin-1betaLupus Erythematosus, SystemicMitochondriaMonocytesAnimalsHumansInterferon Type IMyxovirus Resistance ProteinsInterferon Type IInterleukin-1betaMyxovirus Resistance Proteins

Identifiers

PMID39536711
PMCPMC11965885

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.