ReviewMemorias do Instituto Oswaldo Cruz2024
Plants of the family Lamiaceae as a source of therapeutic agents against Acanthamoeba infections.
Review in Memorias do Instituto Oswaldo Cruz, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
backgroundAcanthamoebae are causative agents of severe and complicated human infections without a standard effective therapy to date. Therefore, the research is focused on the development of new amoebicidal drugs based on the natural products. Plants of the family Lamiaceae are typical with several phenolic secondary metabolites that make them interesting in medical point of view.
objectiveIn this review, we concentrate on anti-Acanthamoeba activities of plant extracts, essential oils, and phytochemicals of Lamiaceae in the published literature.
findingsA total of 13 articles in the research field were found. Totally, 16 plant species belonging to family Lamiaceae were studied against trophozoites and cysts of Acanthamoeba in in vitro conditions. Low toxicity of the Lamiaceae plant extracts to tissue cultures enhances their possible potential for clinical use. The research demonstrated promising trophocidal and cysticidal effects against acanthamoebae. Further research is needed with inclusion of more clinical isolates and in vivo studies. MAIN
conclusionReviewing the related literature highlights the promising amoebicidal activities of plant extracts, essential oils and bioactive compounds of family Lamiaceae. Identifying the active components could lead to production new effective and well-tolerated drugs for the Acanthamoeba infections treatment.
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