ArticleActa cirurgica brasileira2024
Results of the use of human platelet-rich fibrin membrane applied on colorrhaphy in nourished and malnourished rats.
Article in Acta cirurgica brasileira, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the effects of platelet-rich fibrin (PRF) on the healing of intestinal sutures in rats.
methodsForty rats were distributed into four groups. Two groups were treated with a standard diet and considered nourished (I and II). Two other groups were treated with cornmeal and considered malnourished (III and IV). All animals underwent cecotomy and cecorrhaphy. Groups II and IV had sutures overlapped with human PRF membrane. The following parameters were evaluated: animal weight, death, rupture site, rupture pressure, collagen, and reticulin dosage in the suture line.
resultsThe use of PRF did not influence deaths, rupture pressure or rupture location. For malnourished animals, a significant difference was observed in relation to the rupture site, corresponding to the suture line (p = 0.038) and reticulin dosage (p = 0.040), when PRF was used. There was no difference in relation to burst pressures.
conclusionsThe use of PRF did not influence intestinal healing in nourished rats. In the group of malnourished animals, its use favored healing.
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