ArticleScience advances2024
Breaking Abbe's diffraction limit with harmonic deactivation microscopy.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Toward Higher Fatigue Resistance of Photochromic Polymer Layers Containing Novel Diarylethenes.ACS omega · 2026Article
- Evaluating the applicability of computational super-resolution techniques for harmonic generation microscopy.Scientific reports · 2026Article
- Attosecond high-harmonic interferometry probes orbital- and band-dependent dipole phase in magnesium oxide.Science advances · 2026Article
- Digital Holography Using Harmonic Generation from Solids for Reconstruction of Subwavelength Nanostructures.ACS photonics · 2026Article
- All-Optical Nonlinear Real and Fourier-Space Shaping with All-Dielectric Fano Resonant Metasurfaces.ACS nano · 2026Article
- Reconstruction and analysis of pore blockage fouling in ceramic ultrafiltration membranes through FIB-SEM.Nature communications · 2025Article
- Generation Dynamics of Broadband Extreme Ultraviolet Vortex Beams.ACS photonics · 2025Article
- Ultrafast Permittivity Engineering Enables Broadband Enhancement and Spatial Emission Control of Harmonic Generation in ZnO.ACS photonics · 2024Article
- Toward Complete All-Optical Intensity Modulation of High-Harmonic Generation from Solids.ACS photonics · 2024Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonlinear optical microscopy provides elegant means for label-free imaging of biological samples and condensed matter systems. The widespread areas of application could even be increased if resolution was improved, which the famous Abbe diffraction limit now restrains. Super-resolution techniques can break the diffraction limit but most rely on fluorescent labeling. This makes them incompatible with (sub)femtosecond temporal resolution and applications that demand the absence of labeling. Here, we introduce harmonic deactivation microscopy (HADES) for breaking the diffraction limit in nonfluorescent samples. By controlling the harmonic generation process on the quantum level with a second donut-shaped pulse, we confine the third-harmonic generation to three times below the original focus size of a scanning microscope. We demonstrate that resolution improvement by deactivation is more efficient for higher harmonic orders and only limited by the maximum applicable deactivation-pulse fluence. This provides a route toward sub-100-nanometer resolution in a regular nonlinear microscope.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.