ArticleScience advances2024
Frailty or resilience? Hazard-based and cumulative phenotype approaches to discerning signals of health inequality in medieval London.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Integration of the circulating miRNome and clinical information to predict 90-day mortality in elderly COVID-19 subphenotypes.iScience · 2026Article
- From Optimism to Opportunity: New Perspectives on the Osteological Paradox.American journal of biological anthropology · 2026Review
- Sex Differences in Frailty in Milan Over the Last 2000 Years: A Hazards-Based and Cumulative Phenotype Approach.American journal of biological anthropology · 2025Article
- Childhood nutritional stress and later-life health outcomes in medieval England: Evidence from incremental dentine analysis.Science advances · 2025Article
- "We Are the Sons of Our Own Deeds": Comparing Skeletal Health and Frailty Indices in Deceased Individuals Across 2000 Years of Milanese History.American journal of biological anthropology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Bioarchaeology uses human skeletal remains to reconstruct varied experiences of individuals and populations in the past, including patterns of health across time periods and cultural contexts. In the past three decades, bioarchaeological studies have highlighted the concept of "frailty," operationalizing it as increased risk of mortality or cumulative phenotypes. Using data from medieval London cemeteries, we integrate these two approaches to frailty in past populations. First, we estimate the risks of mortality and survivorship (hazard and survival analyses) associated with 10 biomarkers and use these results to construct population-specific frailty and resilience indices. Then, we apply the indices to adult individuals to explore frailty and resilience differentials between males and females in medieval London. Findings suggest that the male-female morbidity-mortality paradox observed in modern populations may not have existed in this context, which may be explained by preferential cultural buffering of men in this patriarchal, urban setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.