Evidence map›Paper›PMID 39536081›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Distinct evolutionary trajectories following loss of RNA interference in

Jun Huang, Connor J Larmore, Shelby J Priest, Ziyan Xu, Fred S Dietrich, Vikas Yadav, Paul M Magwene, Sheng Sun, Joseph Heitman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Unisexual reproduction in the global human fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Whole-chromosome duplications drive antimicrobial resistance inbioRxiv : the preprint server for biology · 2025
    Article
  9. Unisexual reproduction in the global human fungal pathogenbioRxiv : the preprint server for biology · 2025
    Article
  10. Tracing the evolution and genomic dynamics of mating-type loci inbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Transposon load and RNAi loss synergize to drive intraspecies diversity inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Distinct evolutionary trajectories following loss of RNA interference inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jun HuangDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-4071-0926
Connor J LarmoreDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Shelby J PriestDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Ziyan XuDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Fred S DietrichDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.
Vikas YadavDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0003-2650-9035
Paul M MagweneDepartment of Biology, Duke University, Durham, NC 27710.ORCID 0000-0002-7659-2589
Sheng SunDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-2895-1153
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0001-6369-5995

Funding

Rapid production of SARS-CoV-2 molecular clones using CRISPR-based yeast recombineeringR01AI100272 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MADHANI, HITEN D · 2012 to 2025
$11.3M
Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
The Genetic Basis of Virulence in Cryptococcus NeoformansR01AI133654 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN, Paul Mitaari Magwene · 2017 to 2026
$4.7M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI039115-27HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI050113-20HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI133654-07NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI100272NIAID NIH HHS R01 AI133654NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

While increased mutation rates typically have negative consequences in multicellular organisms, hypermutation can be advantageous for microbes adapting to the environment. Previously, we identified two hypermutator

Indexed as

Cryptococcus neoformansRNA InterferenceDNA Transposable ElementsDrug Resistance, FungalEvolution, MolecularFungal ProteinsLoss of Function MutationMutationRetroelementsDNA Transposable ElementsFungal ProteinsRetroelementsantifungal drug resistancehypermutationKDZ transposon

Identifiers

PMID39536081
PMCPMC11588098

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.