ArticleGenomics, proteomics & bioinformatics2025
Pangenome Reveals Gene Content Variations and Structural Variants Contributing to Pig Characteristics.
Article in Genomics, proteomics & bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Imputed whole genome sequence based association pinpoints genetic architecture of labour dystocia of pigs using multi-breed populations.Genetics, selection, evolution : GSE · 2026Article
- The influence of structural variants from 2445 pigs on gene expression and complex traits.Nature communications · 2026Article
- Genome-wide identification and comparative analysis of endogenous retroviruses across five breed-representative pig assemblies.BMC genomics · 2026Article
- Pangenomics for Agricultural Breeding: Construction Strategies, Evidence Integration, and Translational Constraints.Biology · 2026Review
- Conservation of Indigenous Pig Breeds in Vietnam: Genetic Characterization, Conservation Strategies, and Future Perspectives.Biology · 2026Review
- Chromosome-level genome assembly of two Chinese wild boars (Sus scrofa).Scientific data · 2026Article
- Review
- De Novo Assembly of Eight Commercial Crossbred Pig Genomes Provides Insights into the Potential Functional Impact of Structural Variation Hotspots.Biomolecules · 2026Article
- Dynamics of genome evolution in the era of pangenome analysis.Cell genomics · 2026Review
- Pangenomic and machine learning approaches to divergent pathogenic strategies in avianFrontiers in microbiology · 2026Review
- Current State of Fish Reference Genome and Pangenome: Methodologies, Sampling Strategies, Quality Assessment and Future Perspectives to Aquaculture Breeding.Marine biotechnology (New York, N.Y.) · 2025Review
- Genome-wide Genetic Mutations Accumulated in Pigs Genome-edited for Xenotransplantation and Their Filial Generation.Genomics, proteomics & bioinformatics · 2025Article
- A high-throughput screening method for selecting feature SNPs to evaluate breed diversity and infer ancestry.Genome research · 2025Article
- Article
- Chromosome-Level Genome Assembly of the Meishan Pig and Insights into Its Domestication Mechanisms.Animals : an open access journal from MDPI · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pigs are one of the most essential sources of high-quality proteins in human diets. Structural variants (SVs) are a major source of genetic variants associated with diverse traits and evolutionary events. However, the current linear reference genome of pigs restricts the accurate presentation of position information for SVs. In this study, we generated a pangenome of pigs and a genome variation map of 599 deeply sequenced genomes across Eurasia. Additionally, we established a section-wide gene repertoire, revealing that core genes are more evolutionarily conserved than variable genes. Furthermore, we identified 546,137 SVs, their enrichment regions, and relationships with genomic features and found significant divergence across Eurasian pigs. More importantly, the pangenome-detected SVs could complement heritability estimates and genome-wide association studies based only on single nucleotide polymorphisms. Among the SVs shaped by selection, we identified an insertion in the promoter region of the TBX19 gene, which may be related to the development, growth, and timidity traits of Asian pigs and may affect the gene expression. The constructed pig pangenome and the identified SVs in this study provide rich resources for future functional genomic research on pigs.
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