Evidence map›Paper›PMID 39535883›Full record

ArticleMolecular biology of the cell2024

Significantly reduced, but balanced, rates of mitochondrial fission and fusion are sufficient to maintain the integrity of yeast mitochondrial DNA.

Brett T Wisniewski, Jason C Casler, Laura L Lackner

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Inhibition of mitochondrial dynamics inFrontiers in cell and developmental biology · 2026
    Article
  5. Ecm19 coordinates mitochondrial fission and cellular redox homeostasis.Redox report : communications in free radical research · 2025
    Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Brett T WisniewskiDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.
Jason C CaslerDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.
Laura L LacknerDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.

Funding

CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Investigating the molecular mechanism of mitochondrial tetheringR01GM120303 · NIGMS · NORTHWESTERN UNIVERSITY · PI LACKNER, LAURA L · 2017 to 2025
$2.9M
The Functions of Mitochondrial Membrane Contact Sites in Space and TimeF32GM145160 · NIGMS · NORTHWESTERN UNIVERSITY · PI CASLER, JASON · 2022 to 2024
$213k
NIGMS NIH HHS F32 GM145160NIGMS NIH HHS R01 GM120303NIGMS NIH HHS T32 GM008061
6 · The paper itself

Abstract

Mitochondria exist as dynamic tubular networks and the morphology of these networks impacts organelle function and cell health. Mitochondrial morphology is maintained in part by the opposing activities of mitochondrial fission and fusion. Mitochondrial fission and fusion are also required to maintain mitochondrial DNA (mtDNA) integrity. In

Indexed as

DNA, MitochondrialMitochondriaMitochondrial DynamicsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsMitochondrial ProteinsMutationDNA, MitochondrialMitochondrial ProteinsSaccharomyces cerevisiae Proteins

Identifiers

PMID39535883
PMCPMC11656474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.