Observational studyInvestigative ophthalmology & visual science2024
Distortion-Corrected Posterior Ocular Shape in Myopic Eyes Assessed by Ultrawide OCT Detects Deformations Associated With Vision-Threatening Changes.
Observational study in Investigative ophthalmology & visual science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
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Who cites it
7 citing papers in PubMed.
- Motion-corrected Gaussian, mean, and parametric curvature mapping of the posterior eye with pupil-tracked whole-eye OCT.Biomedical optics express · 2026Article
- Nasotemporal Asymmetry in Ocular Biometry as a Biomarker for Myopia Progression in Chinese Children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Associations of Retinal Curvature With Choroidal Thickness and OCTA-Derived Choroidal Flow-Density Metric in High Myopia: A Two-Center OCTA Study of Interocular Asymmetry.Translational vision science & technology · 2026Article
- Choroidal changes and association with Gaussian curvature in high myopic eyes with posterior staphyloma in ultra-wide-field optical coherence tomography angiography.Acta ophthalmologica · 2025Article
- Interocular Posterior Retinal Curvature Asymmetry and Its Relationship With Myopic Differences in Anisometropic Children.Translational vision science & technology · 2025Article
- Interocular Differences in Retinal Curvature in Anisometropic Patients and Their Association With Myopic Degree Differences.Investigative ophthalmology & visual science · 2025Article
- Association Between Dementia and Optical Coherence Tomography Scan Quality.Aging and disease · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Purpose: To develop a quantitative tool for assessing the posterior ocular shape using widefield, volumetric optical coherence tomography (OCT) in eyes with myopia. Methods: This observational, cross-sectional study included 178 eyes from 113 participants. Participants underwent a standardized eye examination, including ocular biometry and a custom ultrawide OCT. True ocular shape was reconstructed by tracing the beam propagation from the system to the posterior eye. Gaussian curvature quantified the localized ocular shape, which was further categorized into five distinct categories. An ocular shape irregularity (OSI) was calculated using principal component analysis. Linear regression with breakpoints analyzed the relationship between ocular shape parameters and axial length (AL). Results: Increased curvature mean and variance were associated with more severe myopia (P < 0.001). Curvature categories (convex, normal, concave, and highly concave) differed significantly between the groups (all P < 0.001). Their correlations with AL revealed significant breakpoints between 27.1 and 27.2 mm. OSI, as a single metric for quantifying ocular shape distortion, was associated with more severe myopia (P < 0.001), and its correlation with AL revealed a breakpoint at 27.2 mm with a fourfold increase in slope steepness beyond this pivot. Determination of OSI was highly reproducible and could also be obtained with fewer scans. Conclusions: Eyes exceeding 27.2 mm in length exhibit pronounced shape changes. Our framework can be seamlessly integrated into commercial OCTs for ocular shape deformation detection, which could aid in identifying eyes with pathologic myopia.
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