Evidence map›Paper›PMID 39535753›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2025

Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in Mycobacterium tuberculosis Complex Isolates in England From 2017 Through 2023.

Elena Ferran, Cathleen Chan, Noorann Sheikh, Martin Dedicoat, Eliza Alexander, Ana Gibertoni-Cruz, James Brown, Esther Robinson, Marc Lipman

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Fluoroquinolone resistance and mutation profiles inFrontiers in public health · 2026
    Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elena FerranNational Mycobacterial Reference Service, UK Health Security Agency, Birmingham, United Kingdom.ORCID 0000-0002-8472-7383
Cathleen ChanNational Mycobacterial Reference Service, UK Health Security Agency, Birmingham, United Kingdom.
Noorann SheikhNational Mycobacterial Reference Service, UK Health Security Agency, Birmingham, United Kingdom.
Martin DedicoatNational Mycobacterial Reference Service, UK Health Security Agency, Birmingham, United Kingdom.
Eliza AlexanderNational Mycobacterial Reference Service, UK Health Security Agency, Birmingham, United Kingdom.
Ana Gibertoni-CruzNational Mycobacterial Reference Service, UK Health Security Agency, Birmingham, United Kingdom.ORCID 0000-0002-9473-2215
James BrownRespiratory Medicine, Royal Free London NHS Foundation Trust, London, United Kingdom.
Esther RobinsonNational Mycobacterial Reference Service, UK Health Security Agency, Birmingham, United Kingdom.ORCID 0009-0003-0913-3627
Marc LipmanRespiratory Medicine, Royal Free London NHS Foundation Trust, London, United Kingdom.ORCID 0000-0001-7501-4448

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found it present in 1.4% overall and 23.9% of multidrug-resistant TB. Routine sequencing allows clinically-relevant resistance surveillance and should be widely adopted.

Indexed as

Antitubercular AgentsDrug Resistance, BacterialFluoroquinolonesMycobacterium tuberculosisTuberculosis, Multidrug-ResistantDrug Resistance, Multiple, BacterialEnglandGenome, BacterialHumansMicrobial Sensitivity TestsWhole Genome SequencingAntitubercular AgentsFluoroquinolonesdrug therapyfluoroquinolone resistanceMycobacterium tuberculosiswhole-genome sequencing

Identifiers

PMID39535753
PMCPMC11912959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.