Evidence map›Paper›PMID 39535654›Full record

ArticleLa Radiologia medica2025

BPE on contrast-enhanced mammography: relationship with breast density, age and menopausal status.

Giuliana Moffa, Francesca Galati, Alessandra Spagnoli, Elena Fabrizi, Roberto Maroncelli, Sara Coppola, Veronica Rizzo, Federica Pediconi

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Article in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Giuliana MoffaDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161, Rome, Italy. giuliana.moffa@uniroma1.it.ORCID http://orcid.org/0000-0002-6595-1611
Francesca GalatiDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161, Rome, Italy.ORCID http://orcid.org/0000-0003-2103-2856
Alessandra SpagnoliDepartment of Public Health and Infectious Diseases, Sapienza-University of Rome, 00161, Rome, Italy.ORCID http://orcid.org/0000-0002-7772-3130
Elena FabriziDepartment of Political Sciences, University of Teramo, 64100, Teramo, Italy.ORCID http://orcid.org/0000-0003-3173-3533
Roberto MaroncelliDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161, Rome, Italy.ORCID http://orcid.org/0009-0006-6626-2478
Sara CoppolaDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161, Rome, Italy.
Veronica RizzoDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161, Rome, Italy.ORCID http://orcid.org/0000-0003-1781-3174
Federica PediconiDepartment of Radiological, Oncological and Pathological Sciences, Sapienza-University of Rome, 00161, Rome, Italy.ORCID http://orcid.org/0000-0002-1432-2137

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis retrospective study aimed to evaluate the relationship between BPE on CEM and breast density, age and menopausal status. MATERIAL AND

methodsOur analysis included all women eligible for CEM as a second-level examination in the diagnostic phase in a 12-month period. CEM were performed on a dedicated low-dose digital mammography unit after the injection of 1.5 ml/kg body weight Iohexol 350 mgI/ml. Both breast composition and BPE were assessed independently by two breast radiologists according to the CEM supplement to the 2013 ACR BI-RADS Mammography. A two-stage ordered probit regression model was fitted to evaluate the relationship between BPE and the other factors considered.

results49 patients were included (median age = 55 years, 28.6% premenopausal and 71.4% postmenopausal). Breast composition was classified as ACR BI-RADS a in 4.1%, ACR BI-RADS b in 36.7%, ACR BI-RADS c in 46.9%, and ACR BI-RADS d in 12.2% of cases, by both Readers. A BPE 1 category was assigned in 53.1-55.1% of patients (by Reader 1 and 2, respectively), BPE 2 in 22.4%, BPE 3 in 18.4-12.2%, and BPE 4 in 6.1-10.2%. Higher breast density was strongly associated with higher levels of BPE, while BPE was not directly associated with age, both in fertile and postmenopausal patients. No significant differences were observed between the two Readers.

conclusionIncreased BPE is associated with a well-established breast cancer risk factor as high breast density, while it was not directly dependent on the other non-modifiable factors considered.

Indexed as

Breast DensityBreast NeoplasmsContrast MediaMammographyMenopauseRadiographic Image EnhancementAdultAgedAge FactorsBreastFemaleHumansIohexolMiddle AgedRetrospective StudiesContrast MediaIohexolBackground parenchymal enhancementBreast compositionBreast densityContrast-enhanced mammography

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PMID39535654

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