Evidence map›Paper›PMID 39535602›Full record

ArticleLangenbeck's archives of surgery2024

Prognostic significance and risk factors of mediastinal lymph node metastasis in esophagogastric junction cancer: a single-center, retrospective study.

Yudai Higuchi, Suguru Maruyama, Katsutoshi Shoda, Yoshihiko Kawaguchi, Ryo Saito, Koichi Takiguchi, Wataru Izumo, Yuki Nakata, Kensuke Shiraishi, Shinji Furuya and 3 more

Abstract read
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In one paragraph

Article in Langenbeck's archives of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yudai HiguchiFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Suguru MaruyamaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan. smaruyama@yamanashi.ac.jp.
Katsutoshi ShodaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Yoshihiko KawaguchiFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Ryo SaitoFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Koichi TakiguchiFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Wataru IzumoFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Yuki NakataFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Kensuke ShiraishiFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Shinji FuruyaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Hidetake AmemiyaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Hiromichi KawaidaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.
Daisuke IchikawaFirst Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 4093898, Yamanashi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the optimal extent of lymph node dissection in esophagogastric junction cancer (EGJC) has been reported, the efficacy of mediastinal lymph node dissection remains unclear. We aimed to identify risk factors for mediastinal lymph node metastasis and its prognostic impact in patients with EGJC.

methodsA total of 100 consecutive patients who underwent curative surgery for EGJC were eligible. We examined the rates of metastasis, prognosis, and therapeutic value index at each mediastinal lymph node station. In addition, multivariate analyses were performed to identify risk factors for mediastinal lymph node metastasis.

resultsThe rates of upper, middle, and lower mediastinal lymph node metastases were 12.0%, 20.7%, and 13.2%, respectively. The 5-year overall survival rate was lower in patients with mediastinal lymph node metastasis than in those without mediastinal lymph node metastasis (11.1% vs. 59.2%, p < 0.01). The therapeutic value index was 0 in patients with upper/middle mediastinal lymph node metastasis, and mediastinal lymph node metastasis was an independent prognostic factor (hazard ratio 6.59, 95% confidence interval [CI] 2.48-17.9, p < 0.01). Additionally, the length of esophageal invasion and the presence of hiatal hernia were independent predictors of mediastinal lymph node metastasis (odds ratio 8.21, 95%CI 1.44-46.8, p = 0.02 and odds ratio 7.13, 95%CI 1.22-41.8, p = 0.03).

conclusionNo survival benefit of mediastinal lymph node dissection was observed. Intensive multidisciplinary treatment could be considered in patients with predicted mediastinal lymph node metastasis, such as those with longer esophageal invasion and those with hiatal hernia.

Indexed as

Esophageal NeoplasmsEsophagogastric JunctionLymphatic MetastasisLymph Node ExcisionMediastinumAdultAgedEsophagectomyFemaleHumansLymph NodesMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesEsophagogastric junctionHiatal herniaLymphatic metastasisMediastinumNeoplasms

Identifiers

PMID39535602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.