Evidence map›Paper›PMID 39535597›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Harnessing the power of miRNAs for precision diagnosis and treatment of male infertility.

Ahmed S Doghish, Elsayed G E Elsakka, Hebatallah Ahmed Mohamed Moustafa, Alaa Ashraf, Sherif S Abdel Mageed, Osama A Mohammed, Mustafa Ahmed Abdel-Reheim, Mohamed Bakr Zaki, Hanan Elimam, Nehal I Rizk and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ahmed S DoghishDepartment of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City , 11829, Cairo, Egypt. ahmed_doghish@azhar.edu.eg.ORCID 0000-0002-0136-7096
Elsayed G E ElsakkaBiochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231, Cairo, Egypt.
Hebatallah Ahmed Mohamed MoustafaDepartment of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Alaa AshrafDepartment of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Sherif S Abdel MageedPharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Osama A MohammedDepartment of Pharmacology, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
Mustafa Ahmed Abdel-ReheimDepartment of Pharmacology, College of Pharmacy, Shaqra University, 11961, Shaqra, Saudi Arabia. m.ahmed@su.edu.sa.ORCID 0000-0002-7728-0923
Mohamed Bakr ZakiDepartment of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Menoufia, Egypt.
Hanan ElimamDepartment of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Menoufia, Egypt.
Nehal I RizkDepartment of Biochemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Nasr City, 11786, Egypt, Cairo.
Sarah A OmranPharmacognosy Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Shimaa A FaragSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Donia G YoussefSchool of Biotechnology, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Ahmed I AbulsoudDepartment of Biochemistry, Faculty of Pharmacy, Heliopolis University, El-Salam City, Cairo, 11785, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infertility is a multifactorial reproductive system disorder, and most infertility cases occur in men. Semen testing is now thought to be the most important diagnostic test for infertile men; nonetheless, because of its limitations, the cause of infertility remains unknown for 40% of infertile men. Semen assessment's shortcomings indicate the need for improved and innovative diagnostic techniques and biomarkers worldwide. Non-coding RNAs with a length of roughly 18-22 nucleotides are called microRNAs (miRNAs). Most of our protein-coding genes are post-transcriptionally regulated by them. These molecules are unusual in bodily fluids, and aberrant variations in their expression can point to specific conditions like infertility. As a result, fresh potential biomarkers for the diagnosis and prognosis of various forms of male infertility may be represented by miRNAs. This review examined the most recent research revealing the association between different miRNAs' functions in male infertility and their expression patterns. Also, it aims to figure out the most recent strategies that could be applied for using such miRNAs as possible therapeutic targets for infertility treatment.

Indexed as

Infertility, MaleMicroRNAsAnimalsBiomarkersHumansMalePrecision MedicineBiomarkersMicroRNAsDiagnosisMale infertilityMiRNAPathogenesis

Identifiers

PMID39535597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.