Evidence map›Paper›PMID 39535579›Full record

ArticleMolecular biology reports2024

Down-regulation of miR-138-5p in PP2A KO mice promoted apoptosis of spermatocytes.

Danni Wang, Xing Liu, Bingyan Chen, Yuwei Shang, Ting Wan, Shu Zhang, Huijun Liu, Yichao Shi, Xia Chen, Huiting Sun

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Danni WangCenter of Reproduction, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University,Changzhou Medical Center, Nanjing Medical University, No. 68 Gehu Road, Jiangsu, Changzhou, 213003, China.
Xing LiuCenter of Reproduction, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University,Changzhou Medical Center, Nanjing Medical University, No. 68 Gehu Road, Jiangsu, Changzhou, 213003, China.
Bingyan ChenCenter of Reproduction, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University,Changzhou Medical Center, Nanjing Medical University, No. 68 Gehu Road, Jiangsu, Changzhou, 213003, China.
Yuwei ShangCenter of Reproduction, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University,Changzhou Medical Center, Nanjing Medical University, No. 68 Gehu Road, Jiangsu, Changzhou, 213003, China.
Ting WanChangzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu Province, 213003, China.
Shu ZhangCenter of Reproduction, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University,Changzhou Medical Center, Nanjing Medical University, No. 68 Gehu Road, Jiangsu, Changzhou, 213003, China.
Huijun LiuCenter of Reproduction, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University,Changzhou Medical Center, Nanjing Medical University, No. 68 Gehu Road, Jiangsu, Changzhou, 213003, China.
Yichao ShiCenter of Reproduction, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University,Changzhou Medical Center, Nanjing Medical University, No. 68 Gehu Road, Jiangsu, Changzhou, 213003, China.
Xia Chen *Center of Reproduction, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University,Changzhou Medical Center, Nanjing Medical University, No. 68 Gehu Road, Jiangsu, Changzhou, 213003, China.
Huiting Sun *Center of Reproduction, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University,Changzhou Medical Center, Nanjing Medical University, No. 68 Gehu Road, Jiangsu, Changzhou, 213003, China. 94sunhuiting@163.com.

Funding

Changzhou Sci & Tech Program CJ20220071Changzhou Sci & Tech Program CJ20230073Changzhou Sci & Tech Program grant no. CJ20220077"Longcheng Medical Star" Health Youth Science and Technology Talent Promotion Project LCYX202201the Science Foundation of Nanjing Medical University Affiliated Changzhou Second People's Hospital 2022K007Youth Program of Changzhou Health Commission QN202233
6 · The paper itself

Abstract

backgroundProtein phosphatase 2 A (PP2A) is known to have a pivotal and diverse functions in various physiological processes. In the previous study, we utilized the cre-loxp system to generate germ cell-specific knockout mice for the PP2A catalytic subunit alpha subunit (Ppp2ca METHODS AND

resultsUsing high-throughput miRNA sequencing of testis tissues and real‑time PCR, we have identified a notable decrease in the expression of miR-138-5p in the testes of Ppp2ca

conclusionOur study indicates that the down-regulation of miR-138-5p in PP2A KO mice, which targets Trps1 to promote spermatocyte apoptosis.

Indexed as

ApoptosisDown-RegulationMice, KnockoutMicroRNAsProtein Phosphatase 2Repressor ProteinsSpermatocytesTestisAnimalsCell LineCell ProliferationGene Expression RegulationMaleMiceMicroRNAsMIRN138 microRNA, mouseProtein Phosphatase 2Repressor ProteinsTrps1 protein, mouseAzoospermiamiR-138-5pPP2ASpermatogenesisTrps1

Identifiers

PMID39535579

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.