Evidence map›Paper›PMID 39535454›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2025

Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies.

Žaneta Železníková, L'ubomíra Nováková, Lubomír Vojtíšek, Luboš Brabenec, Kristína Mitterová, Ivona Morávková, Irena Rektorová

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Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Žaneta ŽelezníkováApplied Neuroscience Research Group, Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic.
L'ubomíra NovákováApplied Neuroscience Research Group, Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic.
Lubomír VojtíšekMultimodal and Functional Neuroimaging Research Group, Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic.
Luboš BrabenecApplied Neuroscience Research Group, Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic.
Kristína MitterováApplied Neuroscience Research Group, Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic.
Ivona MorávkováApplied Neuroscience Research Group, Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic.
Irena RektorováApplied Neuroscience Research Group, Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic.ORCID 0000-0002-5455-4573

Funding

EU Joint Programme - Neurodegenerative Disease Research 8F22005MEYS CR LM2023050MEYS, LRI CZECRIN LM2023049Ministerstvo Školství, Mládeže a Tělovýchovy LX22NPO5107Ministerstvo Zdravotnictví Ceské Republiky NU23J-04-00005
6 · The paper itself

Abstract

backgroundAlthough neuromelanin-sensitive magnetic resonance imaging (NM-MRI) has been used to evaluate early neurodegeneration in Parkinson's disease, studies concentrating on the locus coeruleus (LC) in pre-dementia stages of dementia with Lewy bodies (DLB) are lacking.

objectivesThe aims were to evaluate NM-MRI signal changes in the LC in patients with mild cognitive impairment with Lewy bodies (MCI-LB) compared to healthy controls (HC) and to identify the cognitive correlates of the changes. We also aimed to test the hypothesis of a caudal-rostral α-synuclein pathology spread using NM-MRI of the different LC subparts.

methodsA total of 38 MCI-LB patients and 59 HCs underwent clinical and cognitive testing and NM-MRI of the LC. We calculated the contrast ratio of NM-MRI signal (LC-CR) in the whole LC as well as in its caudal, middle, and rostral MRI slices, and we compared the LC-CR values between the MCI-LB and HC groups. Linear regression analyses were performed to assess the relationship between the LC-CR and cognitive outcomes.

resultsThe MCI-LB group exhibited a significant reduction in the right LC-CR compared to HCs (P = 0.021). The right LC-CR decrease was associated with impaired visuospatial memory in the MCI-LB group. Only the caudal part of the LC exhibited significant LC-CR decreases in MCI-LB patients compared to HCs on both sides (P < 0.0001).

conclusionsThis is the first study that focuses on LC-CRs in MCI-LB patients and analyzes the LC subparts, offering new insights into the LC integrity alterations in the initial stages of DLB and their clinical correlates. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

Cognitive DysfunctionLewy Body DiseaseLocus CoeruleusAgedAged, 80 and overalpha-SynucleinFemaleHumansMagnetic Resonance ImagingMaleMelaninsMiddle AgedNeuropsychological Testsalpha-SynucleinMelaninsneuromelaninlocus coeruleusmild cognitive impairment with Lewy bodiesneuromelanin‐sensitive magnetic resonance imaging

Identifiers

PMID39535454
PMCPMC11832806

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.