Article in The Journal of cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
21 authors.
Florent Arbogast *Laboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire , Strasbourg, France.ORCID 0009-0004-9262-3631
Raquel Sal-Carro *Laboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire , Strasbourg, France.ORCID 0000-0002-4324-5409
Wacym BoufenghourLaboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire , Strasbourg, France.ORCID 0000-0002-2018-3102
Delphine BouisLaboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire , Strasbourg, France.ORCID 0000-0002-4917-3135
Louise Filippi De La PalavesaLaboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire , Strasbourg, France.ORCID 0000-0002-4470-5884
Jean-Daniel FaunyLaboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire , Strasbourg, France.ORCID 0000-0002-1651-8555
Olivier GrisoInstitut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM U1258/CNRS UMR7104 , Illkirch, France.ORCID 0009-0008-8896-4045
Hélène PuccioInstitut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM U1258/CNRS UMR7104 , Illkirch, France.ORCID 0000-0003-4711-2248
Nikolaus RomaniDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-1614-9128
Björn E ClausenInstitute for Molecular Medicine and Paul Klein Center for Immunotherapy (PKZI), University Medical Center of the Johannes Gutenberg-University Mainz , Mainz, Germany.ORCID 0000-0002-2484-7842
Benjamin VoisinLaboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire , Strasbourg, France.ORCID 0000-0003-1314-2908
Christopher G MuellerLaboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire , Strasbourg, France.ORCID 0000-0002-4119-2729
Frédéric Gros *Laboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire , Strasbourg, France.ORCID 0000-0002-6252-4323
Vincent Flacher *Laboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire , Strasbourg, France.ORCID 0000-0002-8648-2615
Funding
ANR AURIGENE ANR-20-CE93-0001ANR AUTOMATE ANR-20-CE15-0018-01ANR ERAPerMed BATMAN ANR-18-PERM-0001Centre National de la Recherche ScientifiqueEquipEx ANR-11-EQPX-022Fondation Arthritis CourtinFrench Centre National de la Recherche ScientifiqueIdEx Unistra ANR-10-IDEX-0002Institut National de la Santé et de la Recherche MédicaleLaboratory of Excellence Medalis ANR-10-LABX-0034Marie Slodowska-Curie Individual Fellowship H2020-MSCA-IF-2019 896095 VirIVITESMinistère de la Recherche et de l'Enseignement SupérieurSFRI-STRAT'US ANR-20-SFRI-0012Strasbourg's Interdisciplinary Thematic Institute (ITI) for Precision MedicineStrasbourg University
6 · The paper itself
Abstract
Macroautophagy (often-named autophagy), a catabolic process involving autophagy-related (Atg) genes, prevents the accumulation of harmful cytoplasmic components and mobilizes energy reserves in long-lived and self-renewing cells. Autophagy deficiency affects antigen presentation in conventional dendritic cells (DCs) without impacting their survival. However, previous studies did not address epidermal Langerhans cells (LCs). Here, we demonstrate that deletion of either Atg5 or Atg7 in LCs leads to their gradual depletion. ATG5-deficient LCs showed metabolic dysregulation and accumulated neutral lipids. Despite increased mitochondrial respiratory capacity, they were unable to process lipids, eventually leading them to ferroptosis. Finally, metabolically impaired LCs upregulated proinflammatory transcripts and showed decreased expression of neuronal interaction receptors. Altogether, autophagy represents a critical regulator of lipid storage and metabolism in LCs, allowing their maintenance in the epidermis.
Indexed as
AutophagyAutophagy-Related Protein 5Autophagy-Related Protein 7EpidermisLangerhans CellsLipid MetabolismAnimalsMiceMice, Inbred C57BLMice, KnockoutMitochondriaAtg5 protein, mouseAtg7 protein, mouseAutophagy-Related Protein 5Autophagy-Related Protein 7
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Epidermal maintenance of Langerhans cells relies on autophagy-regulated lipid metabolism. · full record | OpenQuestion