Evidence map›Paper›PMID 39535364›Full record

ArticleInternational forum of allergy & rhinology2025

Pathologic dural invasion is associated with regional recurrence in olfactory neuroblastoma: A multi-institutional study.

Anthony Tang, Suchet Taori, Nicholas Fung, Joao Paulo Almeida, Pierre-Olivier Champagne, Juan C Fernandez-Miranda, Paul Gardner, Peter H Hwang, Jayakar V Nayak, Chirag Patel and 12 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Anthony TangUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0009-0004-7381-9022
Suchet TaoriUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Nicholas FungDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Joao Paulo AlmeidaDepartment of Neurological Surgery, Mayo Clinic, Jacksonville, Florida, USA.
Pierre-Olivier ChampagneDepartment of Neurological Surgery, Universite Laval, Quebec City, Quebec, Canada.
Juan C Fernandez-MirandaDepartment of Neurological Surgery, Stanford University, Palo Alto, California, USA.
Paul GardnerDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Peter H HwangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
Jayakar V NayakDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.ORCID 0000-0003-4454-0861
Chirag PatelDepartment of Otolaryngology-Head and Neck Surgery, Loyola University, Maywood, Illinois, USA.
Zara M PatelDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.ORCID 0000-0003-2072-982X
Maria Peris CeldaDepartment of Neurological Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Carlos Pinheiro-NetoDepartment of Otolaryngology, Mayo Clinic, Rochester, Minnesota, USA.
Olabisi SanusiDepartment of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA.
Carl SnydermanDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8920-4522
Brian D ThorpDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jamie J Van GompelDepartment of Neurological Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Georgios A ZenonosDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Nathan T ZwagermanDepartment of Neurological Surgery, University of Wisconsin, Milwaukee, Wisconsin, USA.
Eric W WangDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1180-5854
Mathew GeltzeilerDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
Garret ChobyDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3745-2727

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNeck metastases are a poor prognostic factor in olfactory neuroblastoma (ONB). Pathologic dural invasion (pathDI) may increase the risk of neck metastases due to invasion of dural lymphatics. We aim to evaluate the prognostic value of pathDI in predicting rates of neck metastases and recurrence using a large, multicenter database of ONB patients. DATA SOURCES: Retrospective review of a prospective, multicenter database of electronic health records of all patients who presented with ONB between 2005 and 2021 at nine tertiary academic care centers within North America. REVIEW

methodsClinicopathologic features including modified Kadish staging systems, margin status, treatment modalities, Hyams grading, follow-up time, and survival.

resultsOf 258 ONB patients, 189 patients met the inclusion criteria. The 10-year neck recurrence-free survival (neck-RFS) rates were 85.7% (75.6‒97.3) and 61.8% (47.9‒79.8) for patients without and with pathDI, respectively (p = 0.018). Time-to-event multivariable regression analysis found pathDI to have an odds ratios of 9.7 (95% confidence interval [CI] 1.2-80.4, p = 0.04) for neck-RFS and 9.5 for RFS at any site (95% CI 1.1-83.3, p = 0.04).

conclusionIn multivariable analysis, the presence of pathDI appears to be the strongest predictor of neck recurrence and recurrence at any site. Future studies exploring the benefit of elective neck dissection or radiation for patients with pathDI may impact disease management.

Indexed as

Dura MaterEsthesioneuroblastoma, OlfactoryNasal CavityNeoplasm Recurrence, LocalNose NeoplasmsAdolescentAdultAgedFemaleHumansMaleMiddle AgedNeoplasm InvasivenessPrognosisRetrospective StudiesYoung Adultdural invasionesthesioneuroblastomaHyams gradeKadish stagemetastasesolfactory neuroblastomarecurrencesurvivaltreatment

Identifiers

PMID39535364
PMCPMC11970447

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.