Evidence map›Paper›PMID 39535340›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Imaging, biomarkers, and vascular cognitive impairment in China: Rationale and design for the VICA study.

Mei Cui, Zishuo Jin, Yingzhe Wang, Jiwei Jiang, Sisi Peng, Qiang Wei, Shuting Zhang, Qingzhang Tuo, Junchao Xie, Haixia Leng and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Imaging, biomarkers, and vascular cognitive impairment in China: Rationale and design for the VICA study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Mei CuiDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Zishuo JinDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Yingzhe WangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Jiwei JiangBeijing Tiantan Hospital, Capital Medical University, Beijing, China.
Sisi PengDepartment of Neuropsychology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Qiang WeiDepartment of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Shuting ZhangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Qingzhang TuoDepartment of Geriatrics and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Junchao XieDepartment of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Haixia LengDivision of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Hongxing WangDivision of Neuropsychiatry and Psychosomatics, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yanxin ZhaoDepartment of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Peng LeiDepartment of Neurology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jun XuBeijing Tiantan Hospital, Capital Medical University, Beijing, China.
Kai WangDepartment of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Junjian ZhangDepartment of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Yanfeng JiangState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China.
Ding DingInstitute of Neurology, National Center for Neurological Disorders, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Fang XieDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Jintai YuDepartment of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Qiang DongDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
VICA Investigators

Funding

National Key R&D Program of China 2021YFC2500100Scientific and Technological Innovation 2030-Major Projects 2021ZD0201806Scientific and Technological Innovation 2030-Major Projects 2022ZD0211600
6 · The paper itself

Abstract

introductionVascular cognitive impairment (VCI) is highly heterogeneous, with unclear pathogenesis. Individuals with vascular risk factors (VRF), cerebral small vessel disease (CSVD), and stroke are all at risk of developing VCI. To address the growing challenges posed by VCI, the "Vascular, Imaging and Cognition Association of China" (VICA) was established.

methodsVICA aims to recruit 10,000 participants, including 2000 with VRF, 3000 with CSVD, and 5000 stroke patients, to form a nationwide multicenter cohort. The study integrates clinical, neuroimaging, and multi-omics data to better understand VCI heterogeneity, improve disease prediction, and ensure timely diagnosis.

resultsVICA has screened 2045 eligible VRF participants from six communities in Wuhan, Shanghai, and Taizhou, along with 602 CSVD and 1269 stroke patients from 135 hospitals nationwide. Baseline enrollment and follow-up work are still ongoing. DISCUSSION: Establishing a high-quality longitudinal cohort is crucial for understanding VCI pathogenesis and developing novel markers for early screening and diagnosis. HIGHLIGHTS: Establish a large-scale prospective longitudinal cohort comprising 10,000 participants, focusing on the high-risk population of vascular cognitive impairment (VCI) in China. Establish a nationwide three-tier medical network, make full use of resources, and achieve extensive enrollment of patients with cerebral small vessel disease and stroke patients. Utilize multimodal imaging and biomarkers to lay the foundation for constructing more-precise risk models. Introduce eye movement and gait analysis as new methods for assessing cognitive function. Use positron emission tomography to further investigate the interaction between vascular factors and neurodegeneration.

Indexed as

BiomarkersCerebral Small Vessel DiseasesCognitive DysfunctionNeuroimagingAgedChinaCohort StudiesDementia, VascularFemaleHumansLongitudinal StudiesMaleMiddle AgedMulticenter Studies as TopicProspective StudiesRisk FactorsBiomarkersChinacohortcommunityCSVDhospitalimagingomics researchstrokevascular cognitive impairment

Identifiers

PMID39535340
PMCPMC11667496

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.