Evidence map›Paper›PMID 39535318›Full record

SynthesisBritish journal of haematology2025

Red cell specifications for blood group matching in patients with haemoglobinopathies: An updated systematic review and clinical practice guideline from the International Collaboration for Transfusion Medicine Guidelines.

Julia Wolf, Isabelle Blais-Normandin, Aarti Bathla, Homa Keshavarz, Stella T Chou, Arwa Z Al-Riyami, Cassandra D Josephson, Edwin Massey, Heather A Hume, Jacob Pendergrast and 5 more

Abstract readSystematic Review
In one paragraph

Synthesis in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. [Guideline for transfusion management in Chinese children with transfusion-dependent thalassemia (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Guideline
  2. Pooled it
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  6. Review
  7. Article
  8. Article
  9. Analysis of Erythrocyte Membrane Alloantigens.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
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  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Julia WolfBristol Haematology and Oncology Centre, Bristol, UK.ORCID https://orcid.org/0000-0003-0478-508X
Isabelle Blais-NormandinCanadian Blood Services, Vancouver, British Columbia, Canada.
Aarti BathlaCanadian Blood Services, Toronto, Ontario, Canada.
Homa KeshavarzCanadian Blood Services, Ottawa, Ontario, Canada.
Stella T ChouDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Arwa Z Al-RiyamiDepartment of Hematology, Sultan Qaboos University Hospital, University Medical City, Al Koudh, Oman.ORCID https://orcid.org/0000-0001-8649-0650
Cassandra D JosephsonDepartment of Oncology and Pediatrics, Johns Hopkins University School of Medicine, Johns Hopkins All Children's Hospital, Baltimore, Maryland, USA.
Edwin MasseyWelsh Blood Service, Velindre University NHS Trust, Pontyclun, Wales, UK.
Heather A HumeDépartement de Pédiatrie, Université de Montréal, Service d'Hématologie/Oncologie, CHU Sainte-Justine, Montréal, Quebec, Canada.
Jacob PendergrastDepartment of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network, Toronto, Ontario, Canada.
Gregory DenommeGrifols Laboratory Solutions, San Marcos, Texas, USA.ORCID https://orcid.org/0000-0001-8727-1679
Rada M Grubovic RastvorcevaInstitute for Transfusion Medicine of RNM, Skopje, North Macedonia.ORCID https://orcid.org/0000-0002-4885-3323
Sara TrompeterNHS Blood and Transplant, London, UK.ORCID https://orcid.org/0000-0002-7099-8449
Simon J StanworthNHS Blood and Transplant, Oxford, UK.ORCID https://orcid.org/0000-0002-7414-4950
International Collaboration for Transfusion Medicine Guidelines (ICTMG)

Funding

Canadian Blood Services
6 · The paper itself

Abstract

Red blood cell (RBC) antigen matching beyond ABO and RhD is commonly recommended for patients with sickle cell disease (SCD) and thalassaemia. We present an updated systematic literature review to inform evidence-based guidelines on RBC matching. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool was used to develop recommendations. Six new observational studies (4 prospective, 2 retrospective) were identified. The six studies reported on 583 patients in total, including cross-over designs, with sample sizes from 10 to 343. Studies were heterogeneous, utilising varying degrees of RBC matching and different definitions for 'extended' matching. All reported on alloimmunisation. One study reported on molecular matching. The reported prevalence of alloimmunisation using limited matching was 0%-50% and with extended matching was 0%-24%. Eighty-two patients were alloimmunised before study entry. The risk of bias across studies was moderate to critical. The guideline panel recommends that ABO, RhDCcEe, and K-compatible RBCs are selected for individuals with SCD and thalassaemia, even in the absence of alloantibodies, and that RBCs which are antigen-negative to already existing clinically significant antibodies are chosen. There is a need for comparative research to define the benefit, impact, cost-effectiveness, and feasibility of extended RBC matching strategies to prevent alloimmunisation.

Indexed as

Blood Group AntigensBlood Grouping and CrossmatchingErythrocytesHemoglobinopathiesErythrocyte TransfusionHumansPractice Guidelines as TopicTransfusion MedicineBlood Group Antigenshaemoglobinopathiesred cell antigenssickle cell diseasethalassaemia

Identifiers

PMID39535318
PMCPMC11739758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.