Evidence map›Paper›PMID 39535280›Full record

ArticleeLife2024

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties.

Jae Hun Shin, Jooyoung Park, Jaechul Lim, Jaekwang Jeong, Ravi K Dinesh, Stephen E Maher, Jeonghyun Kim, Soyeon Park, Jun Young Hong, John Wysolmerski and 2 more

Abstract read
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In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jae Hun Shin *Integrative Science and Engineering Division, Underwood International College, Yonsei University, Incheon, Republic of Korea.ORCID https://orcid.org/0000-0001-6066-0017
Jooyoung Park *Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-9001-6388
Jaechul LimCollege of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-6075-2656
Jaekwang JeongInternal Medicine, Yale University School of Medicine, New Haven, United States.
Ravi K DineshDepartment of Pathology, Stanford University, Stanford, United States.
Stephen E MaherDepartment of Urology, Yale University School of Medicine, New Haven, United States.
Jeonghyun KimInstitute of Advanced Bio-Industry Convergence, Yonsei University, Seoul, Republic of Korea.
Soyeon ParkInstitute of Advanced Bio-Industry Convergence, Yonsei University, Seoul, Republic of Korea.
Jun Young HongDepartment of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
John WysolmerskiInternal Medicine, Yale University School of Medicine, New Haven, United States.
Jungmin ChoiDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-8614-0973
Alfred L M BothwellDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, United States.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
PMCA2 regulates mammary gland involution and breast cancerR01HD076248 · NICHD · YALE UNIVERSITY · PI WYSOLMERSKI, JOHN J · 2014 to 2024
$4.4M
Regulatory T Cell Control of Intestinal TumorigenesisR01CA168670 · NCI · YALE UNIVERSITY · PI BOTHWELL, ALFRED LM · 2014 to 2018
$2.1M
Heterodimerization of the Calcium-sensing receptor with the GabaB receptors in the breast.R01HD100468 · NICHD · YALE UNIVERSITY · PI WYSOLMERSKI, JOHN J · 2020 to 2024
$2.1M
National Research Foundation of Korea ) RS-2023-00213586NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA168670NCI NIH HHS RO1 CA168670-01NICHD NIH HHS R01 HD076248NICHD NIH HHS R01 HD100468Yonsei University Future-Leading Research Initiative 2023-22-0438
6 · The paper itself

Abstract

Metastasis is the leading cause of cancer-related mortality. Paneth cells provide stem cell niche factors in homeostatic conditions, but the underlying mechanisms of cancer stem cell niche development are unclear. Here, we report that Dickkopf-2 (DKK2) is essential for the generation of cancer cells with Paneth cell properties during colon cancer metastasis. Splenic injection of

Indexed as

Colonic NeoplasmsHepatocyte Nuclear Factor 4Intercellular Signaling Peptides and ProteinsLiver NeoplasmsPaneth CellsAnimalsCell DifferentiationGene Expression Regulation, NeoplasticGene Knockout TechniquesHumansLiverMiceMice, Inbred C57BLOrganoidsPromoter Regions, GeneticSingle-Cell Gene Expression AnalysisDKK2 protein, humanDkk2 protein, mouseHepatocyte Nuclear Factor 4Intercellular Signaling Peptides and ProteinsSox9 protein, mouseSOX9 Transcription Factorcancer biologycolon cancerDKK2metastasismousePaneth cell properties

Identifiers

PMID39535280
PMCPMC11560131

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.