Evidence map›Paper›PMID 39535221›Full record

ArticlemBio2024

Type I interferon signaling in dendritic cells limits direct antigen presentation and CD8

Christopher B Bullock, Leran Wang, Brian C Ware, Ngan Wagoner, Ray A Ohara, Tian-Tian Liu, Pritesh Desai, Bjoern Peters, Kenneth M Murphy, Scott A Handley and 2 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christopher B BullockDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-8081-7867
Leran WangDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Brian C WareDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Ngan WagonerDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Ray A OharaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Tian-Tian LiuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Pritesh DesaiDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Bjoern PetersCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, California, USA.
Kenneth M MurphyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Scott A HandleyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-2143-6570
Thomas E MorrisonDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-1811-2938
Michael S DiamondDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-8791-3165

Funding

Impairment of B cell Responses by Pathogenic Chikungunya VirusesR01AI141436 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DIAMOND, MICHAEL S, MORRISON, THOMAS E · 2019 to 2023
$3.2M
NIAID NIH HHS R01 AI141436
6 · The paper itself

Abstract

Ross River virus (RRV) and other alphaviruses cause chronic musculoskeletal syndromes that are associated with viral persistence, which suggests deficits in immune clearance mechanisms, including CD8

Indexed as

Antigen PresentationCD8-Positive T-LymphocytesDendritic CellsInterferon Type ILymphocytic choriomeningitis virusMice, Inbred C57BLRoss River virusSignal TransductionAlphavirusAlphavirus InfectionsAnimalsEpitopes, T-LymphocyteMiceEpitopes, T-LymphocyteInterferon Type IalphavirusinterferonsT-cell immunityT cellsviral pathogenesis

Identifiers

PMID39535221
PMCPMC11633147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.