Evidence map›Paper›PMID 39535192›Full record

ArticleInfection and immunity2024

A conserved interaction between the effector Sca4 and host clathrin suggests additional contributions for Sca4 during rickettsial infection.

Cassandra J Vondrak, Brandon Sit, Chanakan Suwanbongkot, Kevin R Macaluso, Rebecca L Lamason

Abstract read
In one paragraph

Article in Infection and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Adaptation ofmSphere · 2026
    Article
  2. Review
  3. Article
  4. Hybrid capture RNA-seq defines temporal gene expression inbioRxiv : the preprint server for biology · 2026
    Article
  5. Bioinformatics and biology insights · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Pathogen-induced rerouting of host membrane trafficking.Current opinion in cell biology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Cassandra J VondrakMicrobiology Graduate Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0003-0774-5200
Brandon SitDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0003-2378-3039
Chanakan SuwanbongkotDepartment of Microbiology and Immunology, Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, Alabama, USA.
Kevin R MacalusoDepartment of Microbiology and Immunology, Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, Alabama, USA.ORCID 0000-0001-8537-6100
Rebecca L LamasonDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-2762-7917

Funding

Mechanisms of SFG Rickettsia-Host InteractionsR01AI155489 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI REBECCA L LAMASON · 2021 to 2026
$3.7M
Molecular basis for spotted fever group Rickettsia vector competence in ticksR01AI077784 · NIAID · UNIVERSITY OF SOUTH ALABAMA · PI MACALUSO, KEVIN R. · 2009 to 2019
$3.5M
Investigating genes of unknown function required for Rickettsia parkeri infectionF32AI172121 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SIT, BRANDON YIU CHUNG · 2022 to 2024
$210k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI077784HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F32AI172121NIAID NIH HHS F32 AI172121NIAID NIH HHS R01 AI077784NIAID NIH HHS R01 AI155489
6 · The paper itself

Abstract

Intracellular bacterial pathogens deploy secreted effector proteins that manipulate diverse host machinery and pathways to promote infection. Although many effectors carry out a single function or interaction, there are a growing number of secreted effectors capable of interacting with multiple host factors. However, few effectors secreted by arthropod-borne obligate intracellular

Indexed as

Bacterial ProteinsClathrinHost-Pathogen InteractionsRickettsiaAnimalsClathrin Heavy ChainsEndocytosisHumansProtein BindingRickettsia InfectionsBacterial ProteinsClathrinClathrin Heavy Chainscell-to-cell spreadclathrinhost–pathogen interactionsRickettsia parkerivector-borne diseases

Identifiers

PMID39535192
PMCPMC11629629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.