Evidence map›Paper›PMID 39535140›Full record

ArticleGut microbes

Differential contributions of the gut microbiota and metabolome to pathomechanisms in ulcerative colitis: an

Jonas Poppe, Leen Boesmans, Sara Vieira-Silva, Lise Deroover, Raul Tito, Doris Vandeputte, Greet Vandermeulen, Vicky De Preter, Jeroen Raes, Severine Vermeire and 2 more

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. A Review on the Molecular Dynamics of EnterotypeInternational journal of molecular sciences · 2026
    Review
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  8. Article
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  12. The Herbal PairFood science & nutrition · 2025
    Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jonas PoppeTranslational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0002-8640-2101
Leen BoesmansTranslational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Sara Vieira-SilvaInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID 0000-0002-4616-7602
Lise DerooverTranslational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Raul TitoLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.ORCID 0000-0001-9660-7621
Doris VandeputteLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.ORCID 0000-0003-3019-5585
Greet VandermeulenTranslational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0002-0385-7320
Vicky De PreterTranslational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Jeroen RaesLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-1337-041X
Severine VermeireTranslational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0001-9942-3019
Gwen FalonyInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID 0000-0003-2450-0782
Kristin VerbekeTranslational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0002-5352-7565

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota has been implicated in onset and progression of ulcerative colitis (UC). Here, we assess potential causal involvement of the microbiota and -associated fecal water (FW) metabolome in altering key functional parameters of the colonic epithelium. Fecal samples were collected from

Indexed as

ButyratesColitis, UlcerativeFecesGastrointestinal MicrobiomeMetabolomeAdultAgedBacteroidesCaco-2 CellsColonCytokinesFatty Acids, VolatileFemaleHT29 CellsHumansIntestinal MucosaButyratesCytokinesFatty Acids, Volatilefecal metabolomeGut microbiotapathomechanismsulcerative colitis

Identifiers

PMID39535140
PMCPMC11562902

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.