Evidence map›Paper›PMID 39534868›Full record

ArticleCase reports in oncology

Polyradiculitis as a Neurological Complication Associated with Adagrasib: A Case Report.

Kristofoor E Leeuwenberg, Rob Ter Heine, Johanna M M Gijtenbeek, Michel M van den Heuvel

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Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Kristofoor E LeeuwenbergDepartment of Neurology, Radboud Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands.
Rob Ter HeineDepartment of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.
Johanna M M GijtenbeekDepartment of Neurology, Radboud Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands.
Michel M van den HeuvelDepartment of Pulmonary Diseases, Radboud Research Institute for Medical Innovation, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Adagrasib is an upcoming anticancer treatment for KRAS G12C-mutated non-small-cell lung carcinoma, colorectal cancer and potentially other solid tumors harboring this mutation. It is generally well-tolerated and reports of neurological adverse events so far have been limited. Case Presentation: We present to our best knowledge the first case of a 70-year-old woman who was admitted with polyradiculitis as a treatment-related complication of adagrasib. Symptoms resolved after treatment with prednisone and therapy interruption of adagrasib followed by a permanent dose reduction. After the dose reduction, there was an ongoing effective tumor response at follow-up, and serum concentrations of adagrasib remained within the therapeutic index. Conclusion: Through this case report, we aim to bring attention to the possibility of this side effect, as we believe it is important to be aware of it for future patients undergoing treatment with adagrasib.

Indexed as

AdagrasibNeuro-oncologyNon-small cell lung cancerPolyradiculitisToxicity

Identifiers

PMID39534868
PMCPMC11556857

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