ArticleCureus2024
A Rare Cause of Acquired Non-Wilsonian Hepato-Cerebral Degeneration in a Middle-Aged Woman.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Manganese is an essential trace mineral that has a vital role in maintaining various body functions. Manganese toxicity, referred to as Manganism, causing parkinsonism is a well-known phenomenon that occurs secondary to chronic environmental and occupational exposure to manganese. Patients with underlying chronic liver disease are also susceptible to the toxic accumulation of manganese since it essentially undergoes biliary excretion. At high serum concentrations, manganese can cross the blood-brain barrier and cause neuronal damage. We report an interesting case of a middle-aged woman with underlying chronic liver disease presenting to the medical admissions unit with features suggestive of parkinsonism, dystonia, and cerebellar dysfunction that developed secondary to manganese deposition in the basal ganglia of the brain. The report discusses important radiological features and also lays special emphasis on early recognition, clinical, radiological, and biochemical correlation, and early intervention.
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Registered trials
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