Evidence map›Paper›PMID 39534769›Full record

ArticleERJ open research2024

Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study.

Nicole C Lapinel, Radmila Choate, Timothy R Aksamit, Joseph Feliciano, Kevin L Winthrop, Andreas Schmid, Sebastian Fucile, Mark L Metersky

Abstract read
In one paragraph

Article in ERJ open research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicole C LapinelNorthwell Health, New Hyde Park, NY, USA.
Radmila ChoateUniversity of Kentucky College of Public Health, Lexington, KY, USA.ORCID https://orcid.org/0000-0002-0540-8377
Timothy R AksamitMayo Clinic, Rochester, MN, USA.
Joseph FelicianoInsmed Incorporated, Bridgewater, NJ, USA.
Kevin L WinthropOregon Health and Science University, Portland, OR, USA.
Andreas SchmidUniversity of Kansas Medical Center, Kansas City, KS, USA.
Sebastian FucileInsmed Incorporated, Bridgewater, NJ, USA.
Mark L MeterskyUniversity of Connecticut School of Medicine, Farmington, CT, USA.

Funding

University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
NIA NIH HHS P30 AG072946
6 · The paper itself

Abstract

Background: Exacerbations of noncystic fibrosis bronchiectasis (bronchiectasis) are associated with reduced health-related quality of life and increased mortality, likelihood of hospitalisation and lung function decline. This study investigated patient clinical characteristics associated with exacerbation frequency. Methods: A cross-sectional cohort study of patients ≥18 years with bronchiectasis enrolled in the US Bronchiectasis and Nontuberculous Mycobacteria (NTM) Research Registry (BRR) September 2008-March 2020. Patients were stratified by exacerbation frequency in their 2 years before enrolment. Patient demographics, respiratory symptoms, healthcare resource utilisation, microbiology, modified bronchiectasis severity index (mBSI) and select comorbidities were collected at enrolment. Patient characteristics associated with exacerbation frequency were assessed using a negative binomial model. Results: The study included 2950 patients (mean age 65.6 years; 79.1% female). Frequency of moderate to severe airway obstruction (forced expiratory volume in 1 s (FEV Conclusions: These findings demonstrate a high disease burden, including increased respiratory symptoms, healthcare resource utilisation, and

Identifiers

PMID39534769
PMCPMC11551853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.