ArticleCurrent research in microbial sciences2024
Exploring the genetic progression of MDR1 in
Article in Current research in microbial sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The genetic progression of the MDR1 gene in Methods: We conducted an extensive genetic analysis using methods such as Analysis of Molecular Variance (AMOVA), pairwise population matrices of Nei unbiased genetic distance and identity, PhiPT and Phi'PT values, and Principal Coordinates Analysis (PCoA). The study covered diverse P. falciparum populations from India, Nigeria, Ethiopia, Honduras, China, and Cameroon. Findings: Our findings reveal significant genetic heterogeneity in the MDR1 gene. Populations like India: Odisha (2014) exhibited high allelic richness, indicating diverse drug resistance profiles. Notable genetic divergence was observed, especially between India (2016) and Nigeria (2020), suggesting different evolutionary trajectories in drug resistance. The PCoA analysis highlighted the multi-dimensional genetic variation, reflecting the complex interplay of factors influencing drug resistance in P. falciparum. Interpretation: The comprehensive analysis of P. falciparum's MDR1 gene provides crucial insights into the multi-regional patterns of drug resistance. This knowledge is essential for developing effective malaria control measures and adapting treatment strategies to the evolving genetic diversity of the parasite.
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