Evidence map›Paper›PMID 39534703›Full record

ArticleFrontiers in cellular and infection microbiology2024

Chemokine profile in the serum of patients with leptospirosis.

Iago H de Miranda Mariano, Roberta M Blanco, Camila Eulalio de Souza, Geovanna Silva de Freitas, Paulo Lee Ho, Elizabeth A L Martins, Eliete C Romero, Josefa B da Silva

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. TLR4 competence and mouse models of sublethal leptospirosis.PLoS neglected tropical diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Iago H de Miranda MarianoLaboratory of Bacteriology, Butantan Institute, Sao Paulo, Brazil.
Roberta M BlancoLaboratory of Bacteriology, Adolfo Lutz Institute, Sao Paulo, Brazil.
Camila Eulalio de SouzaLaboratory of Bacteriology, Butantan Institute, Sao Paulo, Brazil.
Geovanna Silva de FreitasLaboratory of Bacteriology, Butantan Institute, Sao Paulo, Brazil.
Paulo Lee HoBioindustrial Division, Butantan Institute, São Paulo, Brazil.
Elizabeth A L MartinsLaboratory of Recombinant Biological, Butantan Institute, São Paulo, Brazil.
Eliete C RomeroLaboratory of Bacteriology, Adolfo Lutz Institute, Sao Paulo, Brazil.
Josefa B da SilvaLaboratory of Bacteriology, Butantan Institute, Sao Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Leptospirosis is a global zoonosis that affects more than one million people per year, with a lethality rate of approximately 15%. Chemokines are crucial in the immune response against Methods: In this study, we present the frequency of Results and discussion: The main findings were that CCL5, CXCL5, and CXCL9 are highly expressed during leptospirosis, indicating a special role of these molecules in the immunity and pathogenesis of the disease. The correlation analysis of detected chemokines CXCL11, CXCL9, CCL3, and CCL2 helps to clarify the role of each cytokine in leptospirosis. The possible use of CCL5 as a biomarker for complementary diagnosis of the disease is suggested.

Indexed as

ChemokinesLeptospiraLeptospirosisAdultBiomarkersChemokine CCL2Chemokine CCL3Chemokine CCL5Chemokine CXCL11Chemokine CXCL9FemaleHumansMaleSerogroupBiomarkersCCL3 protein, humanCCL5 protein, humanChemokine CCL2Chemokine CCL3Chemokine CCL5Chemokine CXCL11Chemokine CXCL9ChemokinesCXCL11 protein, humanCXCL9 protein, humanchemokinesCopenhageni serovardiagnosisLeptospiraleptospirosisprotein interaction

Identifiers

PMID39534703
PMCPMC11554663

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.