ReviewTranslational breast cancer research : a journal focusing on translational research in breast cancer2024
Pathological precision diagnosis and recent advances in HER2 low and ultralow in breast cancer: a narrative review.
Review in Translational breast cancer research : a journal focusing on translational research in breast cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- SEOM-GEICAM-SOLTI clinical guidelines in advanced breast cancer (UPDATE 2025).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Guideline
- Redefining breast cancer: therapeutic opportunities in HER2-low and emerging molecular subtypes.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Repurposing HER2 IHC: Pan-HER2 and Low-HER2.Applied immunohistochemistry & molecular morphology : AIMM · 2026Review
- Development of a prediction model for HER2 low breast cancer using quantitative intra- and peri-tumoral heterogeneity and MRI features on high-spatial resolution ultrafast DCE-MRI.Quantitative imaging in medicine and surgery · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: The novel antibody-drug conjugate (ADC) analogues are emerging in the field of human epidermal growth factor receptor 2 (HER2) low and ultralow breast cancer, and accurate screening of patients with HER2 low expression poses a serious challenge to both pathological testing processes and diagnostic assessment. The purpose is to provide some suggestions on how to correctly understand HER2 low and ultralow breast cancer. Methods: This paper explores the clinicopathological features, immunohistochemical staining and its heterogeneity of HER2 low and ultralow expression breast cancer through literature search. Key Content and Findings: This article mainly elaborates on four aspects: the differences in clinical pathological characteristics and prognosis between HER2 immunohistochemistry (IHC) low expression and ultralow expression, which are suitable for screening new detection methods for HER2 ultralow expression and HER2 unstained expression, the heterogeneity of HER2 low expression and ultralow expression, and the factors affecting the pre detection process of HER2 low expression and ultralow expression. Conclusions: For the precise pathological diagnosis of HER2 ultralow expression and low expression, further standardization of the definition of HER2 low expression is needed to ensure consistency and accuracy in clinical practice. At the same time, it is recommended to reevaluate the HER2 status in the event of disease recurrence or metastasis, even if the previous test result is HER2-0. On the other hand, it is recommended to further improve and optimize detection techniques and methods, reduce false negatives and false positives, and enhance the sensitivity and specificity of detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.