Evidence map›Paper›PMID 39534308›Full record

ArticleJournal of cardiology cases2024

BK polyomavirus nephropathy after heart transplantation: A case report.

Yoichi Iwasaki, Osamu Seguchi, Megumi Ikura, Tetsuya Arisato, Tasuku Hada, Hiroki Mochizuki, Kensuke Kuroda, Seiko Nakajima, Takuya Watanabe, Yasumasa Tsukamoto and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiology cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yoichi IwasakiDepartment of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Osamu SeguchiDepartment of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Megumi IkuraDepartment of Pharmacy, National Cerebral and Cardiovascular Center, Osaka, Japan.
Tetsuya ArisatoDepartment of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Tasuku HadaDepartment of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Hiroki MochizukiDepartment of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Kensuke KurodaDepartment of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Seiko NakajimaDepartment of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Takuya WatanabeDepartment of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Yasumasa TsukamotoDepartment of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Masanobu YanaseDepartment of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Fumiki YoshiharaDepartment of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Yoshihiko IkedaDepartment of Pathology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Kinta HatakeyamaDepartment of Pathology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Satsuki FukushimaDepartment of Cardiac Surgery, National Cerebral and Cardiovascular Center, Osaka, Japan.
Tomoyuki FujitaDepartment of Cardiac Surgery, National Cerebral and Cardiovascular Center, Osaka, Japan.
Norihide FukushimaDepartment of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of BK polyomavirus (BKV) nephropathy (BKVN) after heart transplantation (HTx). The patient was a male with non-ischemic cardiomyopathy who received HTx at the age of 56 years [serum creatinine (sCre) at the time of HTx: 0.89 mg/dl]. Following 3 months of standard triple immunosuppression using tacrolimus, mycophenolate, and corticosteroid, everolimus with reduced tacrolimus therapy was introduced because of cardiac allograft vasculopathy. However, renal function gradually deteriorated. BKVN was diagnosed via positive simian virus 40 antigen staining of renal biopsy specimens 46 months after HTx (sCre: 2.48 mg/dl). Decoy cells and elevated serum BKV load were also observed. After reduction of immunosuppression and monthly low-dose intravenous immunoglobulin administration, the serum BKV load decreased and sCre plateaued while on uneventful clinical course. Since renal function is an important prognostic factor after HTx, early diagnosis and intervention are crucial for successful BKVN treatment. Urine cytology should be performed during post-transplant screening for renal dysfunction. Learning objective: BK polyomavirus nephropathy (BKVN) is a critical issue following solid organ transplantation. However, reports regarding BKVN after heart transplantation (HTx) are sparse, possibly underestimating the significance of BKVN in HTx recipients, therefore case studies are crucial for the understanding of BKVN in HTx recipients. This case clearly demonstrated the clinical course of BKVN and highlights the important clinical implications for the diagnosis and management of BKVN in HTx recipients.

Indexed as

BK polyomavirus nephropathyHeart transplantationImmunosuppressionRenal dysfunction

Identifiers

PMID39534308
PMCPMC11551456

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