Evidence map›Paper›PMID 39534189›Full record

ArticleKidney international reports2024

Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT.

Merve Postalcioglu, Ronit Katz, Simon B Ascher, Trenton Hall, Pranav S Garimella, Stein I Hallan, Joachim H Ix, Michael G Shlipak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Novel protein biomarkers for risk stratification and personalized medicine.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Merve PostalciogluKidney Health Research Collaborative, Veterans Affairs San Francisco Healthcare System and University of California San Francisco, San Francisco, California, USA.
Ronit KatzDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.
Simon B AscherKidney Health Research Collaborative, Veterans Affairs San Francisco Healthcare System and University of California San Francisco, San Francisco, California, USA.
Trenton HallKidney Health Research Collaborative, Veterans Affairs San Francisco Healthcare System and University of California San Francisco, San Francisco, California, USA.
Pranav S GarimellaDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.
Stein I HallanDepartment of Nephrology, St Olav's Hospital and Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Joachim H IxDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.
Michael G ShlipakKidney Health Research Collaborative, Veterans Affairs San Francisco Healthcare System and University of California San Francisco, San Francisco, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Urine epidermal growth factor (uEGF) has been found to be inversely associated with kidney function loss, whereas its associations with cardiovascular disease (CVD) and mortality have not been studied. Methods: We measured baseline uEGF levels among 2346 Systolic Blood Pressure Intervention Trial (SPRINT) participants with an estimated glomerular filtration rate (eGFR) < 60 ml/min per 1.73 m Results: At baseline, the study participants had mean age of 73 ± 9 years, mean eGFR of 46 ± 11 ml/min per 1.73 m Conclusion: Among hypertensive adults with chronic kidney disease (CKD), lower baseline uEGF concentration was associated with faster eGFR decline independent of baseline albuminuria and eGFR; but not with ESKD, AKI, CVD, and all-cause mortality.

Indexed as

cardiovascular diseasechronic kidney diseaseepidermal growth factorkidney tubule biomarkermortalitySPRINT

Identifiers

PMID39534189
PMCPMC11551059

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.