Evidence map›Paper›PMID 39534181›Full record

ArticleToxicology research2024

Efficacy and safety assessment of probiotic

Sohel S Shaikh, Snehal Patel, Anis Malik, Aakash Kumar S

Erratum issuedAbstract read
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In one paragraph

Article in Toxicology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Clinical and In Vitro Safety ofMicroorganisms · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sohel S ShaikhResearch and Development, Pellucid Lifesciences Pvt Ltd, Plot No.:3538, Phase-4, GIDC Industrial Estate, Chhatral, Gandhinagar 382729, Gujarat, India.ORCID https://orcid.org/0000-0001-6012-8020
Snehal PatelDepartment of Pharmacology, Institute of Pharmacy, Nirma University, Sarkhej - Gandhinagar Highway, Gota, Ahmedabad, Gujarat - 382481, India.ORCID https://orcid.org/0000-0002-5002-7530
Anis MalikResearch and Development, Pellucid Lifesciences Pvt Ltd, Plot No.:3538, Phase-4, GIDC Industrial Estate, Chhatral, Gandhinagar 382729, Gujarat, India.ORCID https://orcid.org/0009-0004-5684-3362
Aakash Kumar SDepartment of Pharmacology, Institute of Pharmacy, Nirma University, Sarkhej - Gandhinagar Highway, Gota, Ahmedabad, Gujarat - 382481, India.ORCID https://orcid.org/0000-0002-0953-2631

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveProbiotics offer a potentially new therapeutic approach for the treatment of diarrhea. This study aimed to determine the anti-diarrheal activity of

methodsThe antidiarrheal activity was studied in mice using a castor oil-induced diarrhea model. In the acute toxicity study, the rats were orally fed 2000 mg/kg (4 × 1011 CFU/g) of

resultsIn-vitro MTT assay showed a cytoprotective effect. In acute toxicity study, 2000 mg/kg dose did not cause any alteration in clinical signs, morbidity, or mortality. The findings of the subacute toxicity study showed no alterations in physical appearance and behavioral patterns. Moreover, no significant variations were found in organ weights and hematological and biochemical parameters of the treated groups in the control group. Furthermore, no visible histological changes were observed in the heart, lung, liver, and kidney of the high-dose treatment groups.

conclusionThus, the results of the present study conclude that

Indexed as

Acute toxicityAntidiarrhealBacillus coagulansCytotoxicitySub-acute toxicity

Identifiers

PMID39534181
PMCPMC11551049

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.