The Infected Diabetic Foot: Does Negative Pressure Wound Therapy with Irrigation Reduce Bioburden and Improve Wound Healing?

Mehmet A Suludere, Matthew Malone, Michael C Siah, Arthur Tarricone, Tyler L Coye, Bijan Najafi, Lawrence A Lavery

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in The international journal of lower extremity wounds, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mehmet A SuludereDepartment of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2285-0909

Matthew MaloneInfectious Diseases and Microbiology, School of Medicine, Western Sydney University, Sydney, Australia.

Michael C SiahDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Arthur TarriconeDepartment of Orthopaedic Surgery, University of Texas health Science Center, San Antonio, TX, USA.

Tyler L CoyeDepartment of Surgery, Baylor College of Medicine, Houston, TX, USA.

Bijan NajafiDepartment of Surgery, Baylor College of Medicine, Houston, TX, USA.

Lawrence A LaveryDepartment of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-7920-9952

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to compare the microbial loads of patients with diabetic foot infections treated with negative pressure wound therapy (NPWT) with and without irrigation with polyhexamethylene biguanide (NPWTi-P). This is a post hoc analysis of combined data of two randomized clinical trials. We evaluated people with diabetes treated with moderate and severe diabetic foot infections that required surgery. Tissue specimens were obtained after the initial surgery and following a second planned return to the operating room after 48-72 h of NPWT or NPWTi-P, prior to the second surgery. We used quantitative polymerase chain reaction (qPCR) to determine the total microbial loads (Log

Indexed as

BiguanidesDiabetic FootNegative-Pressure Wound TherapyTherapeutic IrrigationWound HealingWound InfectionAgedBacterial LoadFemaleHumansMaleMiddle AgedTreatment OutcomeBiguanidespolihexanidediabetic foot infectiondiabetic foot woundirrigationnegative pressure wound therapypolyhexamethylene biguanide

Identifiers

PMID39533885

DOI10.1177/15347346241292125

PMCPMC13438004

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.