Evidence map›Paper›PMID 39533716›Full record

ArticleClinical and experimental pediatrics2025

Outcome of pediatric inflammatory bowel disease in Asian children: a multinational 1-year follow-up study.

Pornthep Tanpowpong, Suporn Treepongkaruna, James Guoxian Huang, Kee Seang Chew, Karen Sophia Calixto Mercado, Almida Reodica, Shaman Rajindrajith, Wathsala Hathagoda, Yoko Kin Yoke Wong, Way Seah Lee and 1 more

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Article in Clinical and experimental pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Pornthep TanpowpongDivision of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Suporn TreepongkarunaDivision of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
James Guoxian HuangKhoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Kee Seang ChewDepartment of Pediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Karen Sophia Calixto MercadoDepartment of Pediatrics, Makati Medical Center, Manila, the Philippines.
Almida ReodicaDepartment of Pediatrics, The Medical City, Manila, the Philippines.
Shaman RajindrajithDepartment of Pediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Wathsala HathagodaDepartment of Pediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Yoko Kin Yoke WongEpidemiology, Singapore Clinical Research Institute, Singapore, Singapore.
Way Seah LeeDepartment of Pediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Marion Margaret AwKhoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.

Funding

Faculty of Medicine Ramathibodi Hospital
6 · The paper itself

Abstract

backgroundEpidemiological data on pediatric inflammatory bowel disease (PIBD) have been reported in Asian countries. However, short-term follow-up data, especially in Southeast Asian countries, are limited. PURPOSE: Analyze and compare the baseline and 1-year follow-up (1FU) data for PIBD in Asian children.

methodsThe multinational network included patients with PIBD (aged <19 years) in 5 Asian countries (Malaysia, Philippines, Singapore, Sri Lanka, and Thailand). The diagnosis of PIBD requires gastrointestinal endoscopy. The patients' demographics, clinical information, disease- related outcomes, and treatment data at 1FU were collected.

resultsIn 1995-2021, 368 patients were enrolled (Crohn disease [CD], 56.8%; ulcerative colitis [UC], 38%; and inflammatory bowel disease [IBD]-unclassified, 5.2%). At 1FU, symptoms including diarrhea, bloody stools, and nausea/vomiting subsided in <3%, while abdominal pain persisted in 10.5% of patients with CD and 7.1% of patients with UC. Assessment endoscopy was performed at 1FU in 38% of CD and 31% of UC cases, of which 21% and 23% showed mucosal healing, respectively. Oral prednisolone was administered to 55.3% of patients at diagnosis and 26.8% at 1FU, while infliximab was administered to 2.5% and 7.2% of patients at diagnosis and 1FU, respectively. Independent factors of 1-year clinical remission for CD were oral prednisolone (odds ratio [OR], 0.20; 95% confidence interval [CI], 0.06-0.68), antibiotic use (OR, 0.09; 95% CI, 0.01-0.54), and immunomodulator use (OR, 5.26; 95% CI, 1.52-18.22). A history of weight loss at diagnosis was the only independent risk factor of an IBD flare by 1FU (OR, 2.01; 95% CI, 1.12-3.63).

conclusionThe proportion of children with PIBD and abdominal pain at 1FU remained high. The rates of repeat endoscopy and infliximab use were suboptimal with high rates of systemic corticosteroid use. Quality improvement based on the aforementioned predictors may enhance PIBD care in this geographic region or similar settings.

Indexed as

Bloody stoolsEndoscopyFlareMucosal healingSteroids

Identifiers

PMID39533716
PMCPMC11884952

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