ArticleEuropean journal of medical research2024
Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease.
Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Network meta-analysis of exercise modalities for their effects on micro-inflammation in patients undergoing hemodialysis.European journal of medical research · 2025Pooled it
- Association of systemic inflammatory response index (SIRI) with clinical outcomes in hemodialysis patients: a single-center observational study.BMC nephrology · 2026Observational
- Development and validation of an inflammatory index-based interpretable machine learning model for mortality risk stratification in hemodialysis patients.European journal of medical research · 2026Article
- Monocyte-to-lymphocyte ratio is a promising biomarker in patients initially receiving hemodialysis.Frontiers in nephrology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
BACKGROUND AND
objectivesMaintenance hemodialysis (MHD) patients are at a higher risk of cardiovascular disease (CVD), a common complication and leading cause of death. Persistent micro-inflammation is a unique feature of MHD. Given the established role of inflammation in the pathogenesis of atherosclerosis, this study aims to explore whether novel inflammatory markers (inflammation index) can serve as independent risk factors for CVD in MHD patients.
methodsA cross-sectional survey was conducted on patients from three dialysis centers, categorized into a CVD and non-CVD group based on medical history, laboratory tests, and physical examination. Fasting blood samples were collected from all participants for indicator testing.
resultsThe analysis of 209 patients revealed that 104 had concurrent CVD. Patients in the CVD group were significantly older and exhibited higher anxiety and depression scores. Forward stepwise multivariate logistic regression results identified the inflammation index neutrophil-to-lymphocyte ratio (NLR) (OR = 1.27, 95% CI 1.082-1.491, P < 0.05) and systemic immune-inflammation index (SII) (OR = 1.001, 95% CI 1.0001-1.002, P < 0.05) as independent risk factors for CVD in MHD patients. Receiver operating characteristic (ROC) curve analysis demonstrated that SII, platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and NLR all possess predictive diagnostic values for CVD events in this patient population.
conclusionsHemodialysis centers can utilize simple and cost-effective inflammatory markers to proactively identify patients at risk of CVD. Future research into how inflammation contributes to CVD in MHD is required.
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