Evidence map›Paper›PMID 39533408›Full record

ArticlePilot and feasibility studies2024

Nutritional intervention to enhance recovery after arthroscopic knee surgery in adults: a randomized controlled pilot trial.

Danielle L E Nyman, Callum J Pufahl, Olivia G V Hickey, Tanner Stokes, Craig A Simpson, Jessica C Selinger, Sunita Mathur, Ian Janssen, Lora M Giangregorio, Davide D Bardana and 1 more

Registry-linked trialAbstract read
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In one paragraph

Article in Pilot and feasibility studies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06233825 (Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06233825 nacompletednot on this map

Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults: A Randomized Controlled Pilot Trial

TypeinterventionalSponsorDr. Chris McGlory, PhDRan2024 to 2025Enrolled30ConditionsAnterior Cruciate Ligament Reconstruction, Muscular AtrophyArmsOmega-3 Fatty Acids and Essential Amino Acids, Safflower Oil and Non-Essential Amino Acids
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Danielle L E NymanSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Callum J PufahlSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Olivia G V HickeyDepartment of Surgery, Queen's University, Kingston, ON, Canada.
Tanner StokesSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Craig A SimpsonDepartment of Emergency Medicine, Queen's University, Kingston, ON, Canada.
Jessica C SelingerSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Sunita MathurSchool of Rehabilitation Therapy, Queen's University, Kingston, ON, Canada.
Ian JanssenSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Lora M GiangregorioDepartment of Kinesiology and Health Studies, University of Waterloo, Waterloo, ON, Canada.
Davide D BardanaDepartment of Surgery, Queen's University, Kingston, ON, Canada.
Chris McGlorySchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada. chris.mcglory@queensu.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEssential amino acid (EAA) and omega-3 fatty acid ingestion independently attenuate leg skeletal muscle disuse atrophy in uninjured persons. However, no data exist regarding the effectiveness of combined EAA and omega-3 fatty acid ingestion to mitigate skeletal muscle disuse atrophy in response to anterior cruciate ligament reconstruction (ACLR) surgery. This pilot trial will explore the feasibility of recruitment and retention of ACLR outpatients from a single center across 18 months to consume either a combination of omega-3 fatty acids and EAAs, or a placebo control, for 4 weeks before and 2 weeks after surgery.

methodsThirty adult (≥ 18 years old) ACLR outpatients will be recruited for this single center, double-blind, two-arm randomized controlled feasibility pilot trial. Participants will consume either 5 g⋅day IMPACT: This work will set the foundation for a future randomized controlled trial powered to detect an effect of EAA + omega-3 fatty acid intake on skeletal muscle size or function in response to ACLR surgery.

trial registrationClinicalTrials.gov, NCT06233825. Registered 31 January 2024. https://clinicaltrials.gov/study/NCT06233825?term=NCT06233825&rank=1.

Indexed as

Anterior cruciate ligamentEssential amino acidsMagnetic resonance imagingMuscle protein synthesisOmega-3 fatty acids

Identifiers

PMID39533408
PMCPMC11556091

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.