ArticleLipids in health and disease2024
Association of plasma homocysteine with cardiometabolic multimorbidity: a cross-sectional study in northwest China.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Stress-hyperglycemia ratio, its longitudinal trajectories, and stress-metabolism synergy in predicting cardiometabolic multimorbidity: A nationwide prospective cohort study.The Journal of international medical research · 2026Observational
- Development and validation of a cardiometabolic multimorbidity prediction model in middle-aged and older adults.Scientific reports · 2026Article
- Prognostic impact of the combined effects of lipoprotein(a) and homocysteine in patients with premature myocardial infarction: a prospective cohort study.Frontiers in nutrition · 2026Article
- Relationship between skipping breakfast and metabolic syndrome among adults aged 35-74 years: a cross-sectional study in Northwest China, 2018-2020.Frontiers in nutrition · 2026Article
- Transsulfuration Pathway Products and HInternational journal of molecular sciences · 2025Review
- Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundElevated homocysteine (Hcy) levels have been linked to cardiovascular disease (CVD), but their association with cardiometabolic multimorbidity (CMM) remains uncertain.
methodsData from the baseline survey of the China Northwest Cohort-Ningxia Project (CNC-NX) were used to recruit 22,566 participants. Demographic characteristics, lifestyle factors, and laboratory exam results were collected. Logistic regression was used to evaluate the association between Hcy levels and CMM risk. Restricted cubic splines (RCS) explored potential non-linear relationships, and subgroup analyses assessed the consistency of the association across distinct groups. Sensitivity analysis accounted for cluster variability.
resultsThe final analysis included 18,126 participants. Higher Hcy levels were significantly associated with an increased risk of CMM (adjusted OR = 1.005, P = 0.003), with a linear relationship confirmed by RCS analysis (P for non-linearity = 0.142). There was a stronger association between Hcy-CMM in high-risk people, including elderly, males, and those with high BMI (P < 0.05). No significant association was observed between Hcy levels and more severe types of CMM.
conclusionsElevated Hcy levels are correlated with an increased risk of CMM, warranting further investigation into the underlying mechanisms and potential interventions. Given the individual differences in the Hcy-CMM relationship, targeted comprehensive interventions for high-risk groups are necessary to reduce the risk of CMM.
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