Evidence map›Paper›PMID 39533269›Full record

ArticleJournal of nanobiotechnology2024

Preferential activation of type I interferon-mediated antitumor inflammatory signaling by CuS/MnO

Jinrong Peng, Qian Yang, Rong Lei, Yue Wang, Gansha Liu, Zhiyong Qian

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinrong PengDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. rater.peng@163.com.
Qian YangCenter of Scientific Research, Chengdu Medical College, Chengdu, 610500, Sichuan, China. yoyoyoung@cmc.edu.cn.
Rong LeiCenter of Scientific Research, Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Yue WangCenter of Scientific Research, Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Gansha LiuCenter of Scientific Research, Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Zhiyong QianDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. anderson-qian@163.com.

Funding

National Natural Science Foundation of China 31930067National Natural Science Foundation of China 32171376National Natural Science Foundation of China 32371455Natural Science Foundation of Sichuan Province of China 2024NSFSC0044Science and Technology Program for Distinguished Young Scholar of Sichuan Province 2020JDJQ0048the Key Research and Development Program of Sichuan Province 2024YFFK0205
6 · The paper itself

Abstract

Converting the "cold" tumor microenvironment (TME) to a "hot" milieu has become the prevailing approach for enhancing the response of immune-excluded/immunosuppressed colorectal cancer (CRC) patients to immune checkpoint blockade (ICB) therapy. During this process, inflammation accompanied by different kinds of chemokines/cytokines inevitably occurs. However, some activated inflammatory signals exhibit protumor potency. Therefore, strategies that preferentially activate antitumor inflammatory signaling rather than tumor-promoting signaling need to be developed. Herein, we constructed a STING agonist-loaded CuS/MnO

Indexed as

Colorectal NeoplasmsInterferon Type IManganese CompoundsNanoparticlesOxidesSignal TransductionTumor MicroenvironmentAnimalsApoptosisCell Line, TumorCopperFemaleHumansImmune Checkpoint InhibitorsInflammationMembrane ProteinsCopperImmune Checkpoint InhibitorsInterferon Type IManganese Compoundsmanganese dioxideMembrane ProteinsOxidesProgrammed Cell Death 1 Receptor

Identifiers

PMID39533269
PMCPMC11555826

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.