ArticleBMC public health2024
Global burden and cross-country health inequalities of early-onset colorectal cancer and its risk factors from 1990 to 2021 and its projection until 2036.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neoadjuvant therapy for colorectal cancer from 2015 to 2024: a visual analysis and bibliometric analysis.Frontiers in oncology · 2025Pooled it
- Bioinformatics analysis of proteins in the complement and coagulation cascades in colon cancer: Discovering the potential biomarker SERPINA1.Oncology letters · 2026Article
- Phytochemistry, Bioavailability, and Molecular Mechanisms Underlying Multitarget Anticancer Activity ofNutrients · 2026Review
- Spatiotemporal dynamics, clustering, and ARIMA-based short-term prediction of human brucellosis in Xinjiang, China.BMC infectious diseases · 2026Article
- Cancer Patterns and Barriers to Care Among Socioeconomically Vulnerable Populations in Tripoli: A Descriptive Study from a Local NGO.Diseases (Basel, Switzerland) · 2026Article
- Burden and Forecast of Early-Onset Colorectal Cancer (1990-2038) in Five East Asian Populations: A Systematic Analysis Based on the GBD 2023 Study.Cancer medicine · 2026Article
- ZNF460 inhibits HMGCL and promotes PI3K pathway in colon cancer.Translational cancer research · 2026Article
- Sex-Associated Aspects of Referral, Resectability, and Survival in Patients with Colorectal Liver Metastases (CRLM): A Population-Based Single-Center Study of 1207 MDT-Referred Patients.Annals of surgical oncology · 2026Article
- Screening, Prognostic, and Predictive Molecular Tools for Colorectal Cancer: Recent Advances in the Classical Background.International journal of molecular sciences · 2026Review
- Gene Expression-Based Colorectal Cancer Prediction Using Machine Learning and SHAP Analysis.Genes · 2026Article
- Association between serum lipids and colorectal polyps: a retrospective cross-sectional study.International journal of colorectal disease · 2026Article
- Global burden of early-onset colorectal cancer related to alcohol, tobacco, and physical inactivity: evidence from the global burden of disease 2021.Frontiers in oncology · 2026Article
- Cancer disparities: an extensive review.Ecancermedicalscience · 2026Review
- Global burden and epidemiological determinants of pulmonary arterial hypertension among women aged 55 years and older: a GBD 2023 analysis.Frontiers in medicine · 2026Article
- Nanodynamic Therapy in Colorectal Cancer: Engineering Precision Immunotherapy and Multimodal Synergy.International journal of nanomedicine · 2026Review
- The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection.Ecancermedicalscience · 2026Review
- Global burden and cross-country inequalities in rabies from 1990 to 2021: a systemic analysis of the global burden of disease study 2021.BMC infectious diseases · 2025Article
- Global Burden of Colorectal Cancer in Adolescents and Young Adults From 1990 to 2021: A Systematic Analysis of the Global Burden of Disease Study 2021.Health science reports · 2025Article
- Epidemiological trends of early-onset gastrointestinal cancers from 1990 to 2021 and predictions for 2036: analysis from the global burden of disease study 2021.Annals of medicine · 2025Article
- Burden and projections of diet related early onset gastrointestinal cancers in young adults.NPJ science of food · 2025Article
Corrections and comments
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5 authors.
Funding
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Abstract
purposeTo explore the worldwide, regional, and country-specific burden of early-onset colorectal cancer (EO-CRC) and identify its associated risk factors between 1990 and 2021, and to project its incidence and mortality rates for 2036.
methodsWe acquired data on EO-CRC categorized by gender, socio-demographic index (SDI), and risk factors based on the Global Burden of Disease (GBD) Study 2021. Joinpoint regression analysis was utilized to explore the variation in disease burden. The autoregressive integrated moving average (ARIMA) model was performed to forecast the disease burden up to 2036.
resultsGlobally, the incidence rate, prevalence rate, mortality rate, and disability-adjusted life years (DALYs) rate of EO-CRC were estimated at 5.37 (95%UI: 4.91 to 5.86)/100,000, 34 (95%UI: 30.96 to 37.35)/100,000, 2.01 (95%UI: 1.84 to 2.19)/100,000, and 101.37 (95%: 92.85 to 110.18)/100,000 in 2021. The prevalence and incidence rates of EO-CRC showed an ascending trajectory, whilst the DALYs and mortality rates demonstrated a downward trajectory between 1990 to 2021. The high-middle SDI regions and East Asia exhibited the highest EO-CRC burden among the five SDI regions and 21 GBD regions respectively. A low-whole-grains diet was the chief risk factor contributing to EO-CRC. It was predicted that the age-standardized rate (ASR) of EO-CRC incidence would increase by 5.56%, while the ASR of mortality would decrease by 13.9% globally until 2036.
conclusionThe current and future global burden of EO-CRC is heavy and varies significantly across different regions and countries.
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